[HTML][HTML] Clinical and preclinical evidence for functional interactions of cannabidiol and Δ9-tetrahydrocannabinol

DL Boggs, JD Nguyen, D Morgenson… - …, 2018 - nature.com
The plant Cannabis sativa, commonly called cannabis or marijuana, has been used for its
psychotropic and mind-altering side effects for millennia. There has been growing attention …

Depolarising and Hyperpolarising Actions of GABAA Receptor Activation on Gonadotrophin‐Releasing Hormone Neurones: Towards an Emerging Consensus

AE Herbison, SM Moenter - Journal of neuroendocrinology, 2011 - Wiley Online Library
The gonadotrophin‐releasing hormone (GnRH) neurones represent the final output
neurones of a complex neuronal network that controls fertility. It is now appreciated that …

Marijuana, phytocannabinoids, the endocannabinoid system, and male fertility

SS Du Plessis, A Agarwal, A Syriac - Journal of assisted reproduction and …, 2015 - Springer
Marijuana has the highest consumption rate among all of the illicit drugs used in the USA,
and its popularity as both a recreational and medicinal drug is increasing especially among …

Human laboratory studies on cannabinoids and psychosis

M Sherif, R Radhakrishnan, DC D'Souza… - Biological …, 2016 - Elsevier
Some of the most compelling evidence supporting an association between cannabinoid
agonists and psychosis comes from controlled laboratory studies in humans. Randomized …

[HTML][HTML] Substance abuse and male hypogonadism

Y Duca, A Aversa, RA Condorelli, AE Calogero… - Journal of clinical …, 2019 - mdpi.com
Progressive deterioration of male reproductive function is occurring in Western countries.
Environmental factors and unhealthy lifestyles have been implicated in the decline of …

Measuring disturbance of the endocannabinoid system in psychosis: a systematic review and meta-analysis

A Minichino, M Senior, N Brondino, SH Zhang… - JAMA …, 2019 - jamanetwork.com
Importance The endocannabinoid system (ECS) is a lipid-based endogenous signaling
system. Its relevance to psychosis is through the association between cannabis use and the …

[HTML][HTML] The role of GABA in the regulation of GnRH neurons

M Watanabe, A Fukuda, J Nabekura - Frontiers in neuroscience, 2014 - frontiersin.org
Gonadotropin-releasing hormone (GnRH) neurons form the final common pathway for the
central regulation of reproduction. Gamma-amino butyric acid (GABA) has long been …

[HTML][HTML] Impact of cannabis use on the development of psychotic disorders

ST Wilkinson, R Radhakrishnan, DC D'Souza - Current addiction reports, 2014 - Springer
The link between cannabis use and psychosis comprises three distinct relationships: acute
psychosis associated with cannabis intoxication; acute psychosis that lasts beyond the …

The K2/Spice phenomenon: emergence, identification, legislation and metabolic characterization of synthetic cannabinoids in herbal incense products

LK Brents, PL Prather - Drug metabolism reviews, 2014 - Taylor & Francis
Abstract In 2008, the European Monitoring Center for Drugs and Drug Addiction (EMCDDA)
detected unregulated, psychoactive synthetic cannabinoids (SCBs) in purportedly all-natural …

Minireview: Endocannabinoids and gonadal hormones: bidirectional interactions in physiology and behavior

BB Gorzalka, SS Dang - Endocrinology, 2012 - academic.oup.com
Endocannabinoids act as a major neuromodulatory system in a variety of physiological and
behavioral functions. Three major lines of evidence suggest that the endocannabinoid …