Emerging diversity in lipid–protein interactions
Membrane lipids interact with proteins in a variety of ways, ranging from providing a stable
membrane environment for proteins to being embedded in to detailed roles in complicated …
membrane environment for proteins to being embedded in to detailed roles in complicated …
Characterization of lipid–protein interactions and lipid-mediated modulation of membrane protein function through molecular simulation
The cellular membrane constitutes one of the most fundamental compartments of a living
cell, where key processes such as selective transport of material and exchange of …
cell, where key processes such as selective transport of material and exchange of …
The Ebola virus VP40 matrix layer undergoes endosomal disassembly essential for membrane fusion
SL Winter, G Golani, F Lolicato, M Vallbracht… - The EMBO …, 2023 - embopress.org
Ebola viruses (EBOVs) assemble into filamentous virions, whose shape and stability are
determined by the matrix viral protein 40 (VP40). Virus entry into host cells occurs via …
determined by the matrix viral protein 40 (VP40). Virus entry into host cells occurs via …
Elucidating residue-level determinants affecting dimerization of Ebola virus matrix protein using high-throughput site saturation mutagenesis and biophysical …
YB Narkhede, A Bhardwaj, BB Motsa… - The Journal of …, 2023 - ACS Publications
The Ebola virus (EBOV) is a filamentous virus that acquires its lipid envelope from the
plasma membrane of the host cell it infects. EBOV assembly and budding from the host cell …
plasma membrane of the host cell it infects. EBOV assembly and budding from the host cell …
Protein amphipathic helix insertion: A mechanism to induce membrane fission
One of the fundamental features of biomembranes is the ability to fuse or to separate. These
processes called respectively membrane fusion and fission are central in the homeostasis of …
processes called respectively membrane fusion and fission are central in the homeostasis of …
Phosphatidylserine clustering by the Ebola virus matrix protein is a critical step in viral budding
ML Husby, S Amiar, LI Prugar, EA David, CB Plescia… - EMBO …, 2022 - embopress.org
Phosphatidylserine (PS) is a critical lipid factor in the assembly and spread of numerous
lipid‐enveloped viruses. Here, we describe the ability of the Ebola virus (EBOV) matrix …
lipid‐enveloped viruses. Here, we describe the ability of the Ebola virus (EBOV) matrix …
Lipid–protein interactions in virus assembly and budding from the host cell plasma membrane
BB Motsa, RV Stahelin - Biochemical Society Transactions, 2021 - portlandpress.com
Lipid enveloped viruses contain a lipid bilayer coat that protects their genome to help
facilitate entry into the new host cell. This lipid bilayer comes from the host cell which they …
facilitate entry into the new host cell. This lipid bilayer comes from the host cell which they …
Ebola virus VP40 modulates cell cycle and biogenesis of extracellular vesicles
ML Pleet, J Erickson, C DeMarino… - The Journal of …, 2018 - academic.oup.com
Background Ebola virus (EBOV) mainly targets myeloid cells; however, extensive death of T
cells is often observed in lethal infections. We have previously shown that EBOV VP40 in …
cells is often observed in lethal infections. We have previously shown that EBOV VP40 in …
Ebola Virus Matrix Protein VP40 Single Mutations G198R and G201R Significantly Enhance Plasma Membrane Localization
MD Cioffi, T Sharma, BB Motsa… - The Journal of …, 2024 - ACS Publications
Viral proteins frequently undergo single or multiple amino acid mutations during replication,
which can significantly alter their functionality. The Ebola virus matrix protein VP40 is …
which can significantly alter their functionality. The Ebola virus matrix protein VP40 is …
Host and viral proteins modulating ebola and marburg virus egress
TB Gordon, JA Hayward, GA Marsh, ML Baker… - Viruses, 2019 - mdpi.com
The filoviruses Ebolavirus and Marburgvirus are among the deadliest viral pathogens known
to infect humans, causing emerging diseases with fatality rates of up to 90% during some …
to infect humans, causing emerging diseases with fatality rates of up to 90% during some …