Emerging diversity in lipid–protein interactions

V Corradi, BI Sejdiu, H Mesa-Galloso… - Chemical …, 2019 - ACS Publications
Membrane lipids interact with proteins in a variety of ways, ranging from providing a stable
membrane environment for proteins to being embedded in to detailed roles in complicated …

Characterization of lipid–protein interactions and lipid-mediated modulation of membrane protein function through molecular simulation

MP Muller, T Jiang, C Sun, M Lihan, S Pant… - Chemical …, 2019 - ACS Publications
The cellular membrane constitutes one of the most fundamental compartments of a living
cell, where key processes such as selective transport of material and exchange of …

The Ebola virus VP40 matrix layer undergoes endosomal disassembly essential for membrane fusion

SL Winter, G Golani, F Lolicato, M Vallbracht… - The EMBO …, 2023 - embopress.org
Ebola viruses (EBOVs) assemble into filamentous virions, whose shape and stability are
determined by the matrix viral protein 40 (VP40). Virus entry into host cells occurs via …

Elucidating residue-level determinants affecting dimerization of Ebola virus matrix protein using high-throughput site saturation mutagenesis and biophysical …

YB Narkhede, A Bhardwaj, BB Motsa… - The Journal of …, 2023 - ACS Publications
The Ebola virus (EBOV) is a filamentous virus that acquires its lipid envelope from the
plasma membrane of the host cell it infects. EBOV assembly and budding from the host cell …

Protein amphipathic helix insertion: A mechanism to induce membrane fission

MA Zhukovsky, A Filograna, A Luini, D Corda… - Frontiers in cell and …, 2019 - frontiersin.org
One of the fundamental features of biomembranes is the ability to fuse or to separate. These
processes called respectively membrane fusion and fission are central in the homeostasis of …

Phosphatidylserine clustering by the Ebola virus matrix protein is a critical step in viral budding

ML Husby, S Amiar, LI Prugar, EA David, CB Plescia… - EMBO …, 2022 - embopress.org
Phosphatidylserine (PS) is a critical lipid factor in the assembly and spread of numerous
lipid‐enveloped viruses. Here, we describe the ability of the Ebola virus (EBOV) matrix …

Lipid–protein interactions in virus assembly and budding from the host cell plasma membrane

BB Motsa, RV Stahelin - Biochemical Society Transactions, 2021 - portlandpress.com
Lipid enveloped viruses contain a lipid bilayer coat that protects their genome to help
facilitate entry into the new host cell. This lipid bilayer comes from the host cell which they …

Ebola virus VP40 modulates cell cycle and biogenesis of extracellular vesicles

ML Pleet, J Erickson, C DeMarino… - The Journal of …, 2018 - academic.oup.com
Background Ebola virus (EBOV) mainly targets myeloid cells; however, extensive death of T
cells is often observed in lethal infections. We have previously shown that EBOV VP40 in …

Ebola Virus Matrix Protein VP40 Single Mutations G198R and G201R Significantly Enhance Plasma Membrane Localization

MD Cioffi, T Sharma, BB Motsa… - The Journal of …, 2024 - ACS Publications
Viral proteins frequently undergo single or multiple amino acid mutations during replication,
which can significantly alter their functionality. The Ebola virus matrix protein VP40 is …

Host and viral proteins modulating ebola and marburg virus egress

TB Gordon, JA Hayward, GA Marsh, ML Baker… - Viruses, 2019 - mdpi.com
The filoviruses Ebolavirus and Marburgvirus are among the deadliest viral pathogens known
to infect humans, causing emerging diseases with fatality rates of up to 90% during some …