Abstract Objective Vascular dementia (VaD) is the second most common cause of dementia
and a major health concern worldwide. A comprehensive review on VaD is warranted for …

Abstract Brain arteriolosclerosis (B-ASC), characterized by pathologic arteriolar wall
thickening, is a common finding at autopsy in aged persons and is associated with cognitive …

Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown.
We conducted a multiancestry genome-wide-association meta-analysis in 521,612 …

White matter hyperintensities (WMH) are the most common brain-imaging feature of cerebral
small vessel disease (SVD), hypertension being the main known risk factor. Here, we …

Cerebral small vessel disease (cSVD) is a leading cause of ischaemic and haemorrhagic
stroke and a major contributor to dementia. Covert cSVD, which is detectable with brain MRI …

Stroke, a leading cause of long-term disability and death worldwide, has a heritable
component. Recent gene discovery efforts have expanded the number of known single …

Cerebral small vessel disease is a major cause of stroke and dementia, but its genetic basis
is incompletely understood. We perform a genetic study of three MRI markers of the disease …

Understanding molecular mechanisms involved in vascular aging is essential to develop
novel interventional strategies for treatment and prevention of age-related vascular …

Background and Purpose: Periventricular white matter hyperintensities (WMH; PVWMH) and
deep WMH (DWMH) are regional classifications of WMH and reflect proposed differences in …

Intracerebral haemorrhage and small vessel ischaemic stroke (SVS) are the most acute
manifestations of cerebral small vessel disease, with no established preventive approaches …