Mitochondrial SIRT3 and neurodegenerative brain disorders
Sirtuins are highly conserved NAD+ dependent class III histone deacetylases and catalyze
deacetylation and ADP ribosylation of a number of non-histone proteins. Since, they require …
deacetylation and ADP ribosylation of a number of non-histone proteins. Since, they require …
Hippocampus mitochondrial MnSOD activation by a SIRT3 activator, honokiol, correlates with its deacetylation and upregulation of FoxO3a and PGC1α in a rat model …
We have recently reported that honokiol (HKL), by activating mitochondrial SIRT3,
normalizes reactive oxygen species level and mitochondrial integrity in hippocampus of the …
normalizes reactive oxygen species level and mitochondrial integrity in hippocampus of the …
Lactoferrin averts neurological and behavioral impairments of thioacetamide-induced hepatic encephalopathy in rats via modulating HGMB1/TLR-4/MyD88/Nrf2 …
RM Essam, MA Saadawy, M Gamal, RM Abdelsalam… - …, 2023 - Elsevier
Hepatic encephalopathy (HE) is a life-threatening disease caused by acute or chronic liver
failure manifested by aberrant CNS changes. In the present study, we aimed to explore the …
failure manifested by aberrant CNS changes. In the present study, we aimed to explore the …
Effect of berberine against cognitive deficits in rat model of thioacetamide-induced liver cirrhosis and hepatic encephalopathy (behavioral, biochemical, molecular and …
Background: Liver cirrhosis (LC) is one of the chronic liver diseases with high disability and
mortality accompanying hepatic encephalopathy (HE) followed by cognitive dysfunctions. In …
mortality accompanying hepatic encephalopathy (HE) followed by cognitive dysfunctions. In …
Sirtuin‐3 activation by honokiol restores mitochondrial dysfunction in the hippocampus of the hepatic encephalopathy rat model of ammonia neurotoxicity
The neurotoxic level of ammonia in the brain during liver cirrhosis causes a nervous system
disorder, hepatic encephalopathy (HE), by affecting mitochondrial functions. Sirtuin‐3 …
disorder, hepatic encephalopathy (HE), by affecting mitochondrial functions. Sirtuin‐3 …
Amelioration of Hepatic Encephalopathy Using Dunaliella salina Microalgae in Rats: Modulation of Hyperammonemia/TLR4
FK El-Baz, R Elgohary, A Salama - Biomed Research …, 2021 - Wiley Online Library
Hepatic encephalopathy (HE) is a neuropsychiatric disease that is developed as a
complication of both acute and chronic liver failure affecting psychomotor dysfunction …
complication of both acute and chronic liver failure affecting psychomotor dysfunction …
SIRT1 activation by resveratrol reverses atrophy of apical dendrites of hippocampal CA1 pyramidal neurons and neurobehavioral impairments in moderate grade …
A Khanna, S Chakraborty, SJ Tripathi… - Journal of chemical …, 2020 - Elsevier
A preliminary observation about resveratrol (RSV) dependent normalization of inflammatory
and apoptotic factors in the cortex of hyperammonemic rat model of moderate grade hepatic …
and apoptotic factors in the cortex of hyperammonemic rat model of moderate grade hepatic …
[PDF][PDF] Comparison of effects of devascularization versus shunt on patients with portal hypertension: a meta-analysis
GQ Zong, Y Fei, RM Liu - Chirurgia (Bucur), 2015 - revistachirurgia.ro
Objective: To systematically evaluate the effectiveness of devascularization and shunt on
patients with portal hypertension. Methods: Relevant studies compared devascularization …
patients with portal hypertension. Methods: Relevant studies compared devascularization …
[HTML][HTML] The effects of concurrent treatment of silymarin and lactulose on memory changes in cirrhotic male rats
Results: Our findings showed that treatment with SM+ LAC effectively increased PA latency,
compared with the control group. The results showed that the administration of LAC and …
compared with the control group. The results showed that the administration of LAC and …
Bacopa monnieri Extract (CDRI‐08) Modulates the NMDA Receptor Subunits and nNOS‐Apoptosis Axis in Cerebellum of Hepatic Encephalopathy Rats
P Mondal, SK Trigun - Evidence‐Based Complementary and …, 2015 - Wiley Online Library
Hepatic encephalopathy (HE), characterized by impaired cerebellar functions during chronic
liver failure (CLF), involves N‐methyl‐D‐aspartate receptor (NMDAR) overactivation in the …
liver failure (CLF), involves N‐methyl‐D‐aspartate receptor (NMDAR) overactivation in the …