[HTML][HTML] Epigenomic signatures reveal mechanistic clues and predictive markers for autism spectrum disorder
JM LaSalle - Molecular psychiatry, 2023 - nature.com
Autism spectrum disorder (ASD) comprises a heterogeneous group of neurodevelopmental
outcomes in children with a commonality in deficits in social communication and language …
outcomes in children with a commonality in deficits in social communication and language …
[HTML][HTML] In silico cancer research towards 3R
Background Improving our understanding of cancer and other complex diseases requires
integrating diverse data sets and algorithms. Intertwining in vivo and in vitro data and in …
integrating diverse data sets and algorithms. Intertwining in vivo and in vitro data and in …
[HTML][HTML] Landscape of mSWI/SNF chromatin remodeling complex perturbations in neurodevelopmental disorders
AM Valencia, A Sankar, PJ van der Sluijs… - Nature Genetics, 2023 - nature.com
DNA sequencing-based studies of neurodevelopmental disorders (NDDs) have identified a
wide range of genetic determinants. However, a comprehensive analysis of these data, in …
wide range of genetic determinants. However, a comprehensive analysis of these data, in …
TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion
Abstract Exhausted CD8+ T (Tex) cells in chronic infections and cancer have limited effector
function, high co-expression of inhibitory receptors and extensive transcriptional changes …
function, high co-expression of inhibitory receptors and extensive transcriptional changes …
Large-scale mapping and mutagenesis of human transcriptional effector domains
Human gene expression is regulated by more than 2,000 transcription factors and chromatin
regulators,. Effector domains within these proteins can activate or repress transcription …
regulators,. Effector domains within these proteins can activate or repress transcription …
[HTML][HTML] Chromatin accessibility dynamics during iPSC reprogramming
Cell-fate decisions remain poorly understood at the chromatin level. Here, we map
chromatin remodeling dynamics during induction of pluripotent stem cells. ATAC-seq …
chromatin remodeling dynamics during induction of pluripotent stem cells. ATAC-seq …
[HTML][HTML] Cell type-specific transcriptional programs in mouse prefrontal cortex during adolescence and addiction
Coordinated activity-induced transcriptional changes across multiple neuron subtypes of the
prefrontal cortex (PFC) play a pivotal role in encoding and regulating major cognitive …
prefrontal cortex (PFC) play a pivotal role in encoding and regulating major cognitive …
[HTML][HTML] Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis
J Argemi, MU Latasa, SR Atkinson, IO Blokhin… - Nature …, 2019 - nature.com
Alcoholic hepatitis (AH) is a life-threatening condition characterized by profound
hepatocellular dysfunction for which targeted treatments are urgently needed. Identification …
hepatocellular dysfunction for which targeted treatments are urgently needed. Identification …
Profiling the genetic determinants of chromatin accessibility with scalable single-cell CRISPR screens
N Liscovitch-Brauer, A Montalbano, J Deng… - Nature …, 2021 - nature.com
CRISPR screens have been used to connect genetic perturbations with changes in gene
expression and phenotypes. Here we describe a CRISPR-based, single-cell combinatorial …
expression and phenotypes. Here we describe a CRISPR-based, single-cell combinatorial …
[HTML][HTML] Decoding chromatin states by proteomic profiling of nucleosome readers
DNA and histone modifications combine into characteristic patterns that demarcate
functional regions of the genome,. While many 'readers' of individual modifications have …
functional regions of the genome,. While many 'readers' of individual modifications have …