Atrial natriuretic factor and brain natriuretic peptide are two important biomarkers in clinical
cardiology. These two natriuretic peptide hormones are encoded by the paralogous genes …

If unifying principles could be revealed for how the same genome encodes different
eukaryotic cells and for how genetic variability and environmental input are integrated to …

A genetic etiology is identified for one-third of patients with congenital heart disease (CHD),
with 8% of cases attributable to coding de novo variants (DNVs). To assess the contribution …

Heart failure (HF) is driven by the interplay between regulatory transcription factors and
dynamic alterations in chromatin structure. Pathologic gene transactivation in HF is …

Background: Cardiovascular disease is associated with epigenomic changes in the heart;
however, the endogenous structure of cardiac myocyte chromatin has never been …

RNA splicing is a major contributor to total transcriptome complexity; however, the functional
role and regulation of splicing in heart failure remain poorly understood. Here, we used a …

INTRODUCTION Cardiac excitation-contraction (EC) coupling refers to a cascade of Ca2+-
mediated events whereby membrane depolarization leads to cell contraction. At the …

Pharmacological histone deacetylase (HDAC) inhibitors attenuate pathological cardiac
remodeling and hypertrophic gene expression; yet, the direct histone targets remain poorly …

BRD4 governs pathological cardiac gene expression by binding acetylated chromatin,
resulting in enhanced RNA polymerase II (Pol II) phosphorylation and transcription …

Animal genomes contain a code for construction of the body plan from a fertilized egg.
Understanding how genome information is deciphered to create the complex multilayered …