Lysosomes are essential catabolic organelles with an acidic lumen and dozens of hydrolytic
enzymes. The detrimental consequences of lysosomal leakage have been well known since …

Aim of the review This study aimed to reveal the classical signal pathways and important
potential targets of traditional Chinese medicine (TCM) for treating Alzheimer's disease (AD) …

Celastrol, triptolide and triptonide are the most significant active ingredients of Tripterygium
wilfordii Hook F (TWHF). In 2007, the 'Cell'journal ranked celastrol, triptolide, artemisinin …

Macroautophagy/autophagy is a conserved catabolic pathway that is vital for maintaining
cell homeostasis and promoting cell survival under stressful conditions. Dysregulation of …

Although Alzheimer's disease is the most pervasive neurodegenerative disorder, the
mechanism underlying its development is still not precisely understood. Available data …

Dysfunction of lysosomes, the primary hydrolytic organelles in animal cells, is frequently
associated with aging and age‐related diseases. At the cellular level, lysosomal dysfunction …

A robust preclinical disease model is a primary requirement to understand the underlying
mechanisms, signaling pathways, and drug screening for human diseases. Although various …

Pyrazolines are a significant class of heterocyclic compounds with essential biological
activities. They are quite stable, which has inspired medicinal chemists to experiment with …

Aberrant amyloid-β (Aβ) fibrillation is the key event in Alzheimer's disease (AD), the
depolymerization and removal of which are being pursued with enthusiasm. Herein, a …

Alzheimer disease (AD) is the most common neurodegenerative disease. Unfortunately,
current effective therapeutics for AD are limited and thus the discovery of novel anti-AD …