Lysosomal quality control: molecular mechanisms and therapeutic implications
Lysosomes are essential catabolic organelles with an acidic lumen and dozens of hydrolytic
enzymes. The detrimental consequences of lysosomal leakage have been well known since …
enzymes. The detrimental consequences of lysosomal leakage have been well known since …
[HTML][HTML] Signal pathways in the treatment of Alzheimer's disease with traditional Chinese medicine
MR Ding, YJ Qu, B Hu, HM An - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Aim of the review This study aimed to reveal the classical signal pathways and important
potential targets of traditional Chinese medicine (TCM) for treating Alzheimer's disease (AD) …
potential targets of traditional Chinese medicine (TCM) for treating Alzheimer's disease (AD) …
[HTML][HTML] A comprehensive review on celastrol, triptolide and triptonide: Insights on their pharmacological activity, toxicity, combination therapy, new dosage form and …
J Song, GN He, L Dai - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Celastrol, triptolide and triptonide are the most significant active ingredients of Tripterygium
wilfordii Hook F (TWHF). In 2007, the 'Cell'journal ranked celastrol, triptolide, artemisinin …
wilfordii Hook F (TWHF). In 2007, the 'Cell'journal ranked celastrol, triptolide, artemisinin …
Transcriptional regulation of autophagy and its implications in human disease
Y Lei, DJ Klionsky - Cell Death & Differentiation, 2023 - nature.com
Macroautophagy/autophagy is a conserved catabolic pathway that is vital for maintaining
cell homeostasis and promoting cell survival under stressful conditions. Dysregulation of …
cell homeostasis and promoting cell survival under stressful conditions. Dysregulation of …
The role of glial autophagy in Alzheimer's disease
A Litwiniuk, GR Juszczak, AM Stankiewicz… - Molecular …, 2023 - nature.com
Although Alzheimer's disease is the most pervasive neurodegenerative disorder, the
mechanism underlying its development is still not precisely understood. Available data …
mechanism underlying its development is still not precisely understood. Available data …
Preclinical models for Alzheimer's disease: past, present, and future approaches
A robust preclinical disease model is a primary requirement to understand the underlying
mechanisms, signaling pathways, and drug screening for human diseases. Although various …
mechanisms, signaling pathways, and drug screening for human diseases. Although various …
Pyrazoline containing compounds as therapeutic targets for neurodegenerative disorders
Pyrazolines are a significant class of heterocyclic compounds with essential biological
activities. They are quite stable, which has inspired medicinal chemists to experiment with …
activities. They are quite stable, which has inspired medicinal chemists to experiment with …
Nanoparticle cluster depolymerizes and removes amyloid fibrils for Alzheimer's disease treatment
Q Feng, N Wang, X Zhang, Y Mei, R Fu, J Chen… - Nano Today, 2023 - Elsevier
Aberrant amyloid-β (Aβ) fibrillation is the key event in Alzheimer's disease (AD), the
depolymerization and removal of which are being pursued with enthusiasm. Herein, a …
depolymerization and removal of which are being pursued with enthusiasm. Herein, a …
Celastrol, a TFEB (transcription factor EB) agonist, is a promising drug candidate for Alzheimer disease
Alzheimer disease (AD) is the most common neurodegenerative disease. Unfortunately,
current effective therapeutics for AD are limited and thus the discovery of novel anti-AD …
current effective therapeutics for AD are limited and thus the discovery of novel anti-AD …