Some bacterial pathogens modulate signaling pathways of eukaryotic cells in order to
subvert the host response for their own benefit, leading to successful colonization and …

Bacteria and fungi constitute important organisms in many ecosystems, in particular
terrestrial ones. Both organismal groups contribute significantly to biogeochemical cycling …

In an attempt to identify and characterize how symbiotic bacteria of the gut microbiota affect
the molecular and cellular mechanisms of epithelial homeostasis, intestinal epithelial cells …

Legionella pneumophila utilizes the Dot/Icm type IVB secretion system to deliver hundreds
of effector proteins inside eukaryotic cells to ensure intracellular replication. Our …

The cycle inhibiting factors (Cif), produced by pathogenic bacteria isolated from vertebrates
and invertebrates, belong to a family of molecules called cyclomodulins that interfere with …

Legionella pneumophila is a ubiquitous, pathogenic, Gram-negative bacterium responsible
for legionellosis. Like many other amoeba-resistant microorganisms, L. pneumophila resists …

Cycle inhibiting factors (Cifs) are type III secreted effectors produced by diverse pathogenic
bacteria. Cifs are “cyclomodulins” that inhibit the eukaryotic host cell cycle and also hijack …

Many enteric pathogens employ a type III secretion system (T3SS) to translocate effector
proteins directly into the host cell cytoplasm, where they subvert signalling pathways of the …

The bacterial effector protein cycle inhibiting factor (CIF) converts glutamine 40 of NEDD8 to
glutamate (Q40E), causing cytopathic effects and inhibiting cell proliferation. Although these …

Photorhabdus asymbiotica is unique among the entomopathogenic bacteria of this genus in
also being able to infect humans, leading to its isolation from some clinical samples. Recent …