Signaling pathways and their potential therapeutic utility in esophageal squamous cell carcinoma

LK Kadian, M Arora, CP Prasad, R Pramanik… - Clinical and …, 2022 - Springer
Esophageal cancer is a complex gastrointestinal malignancy with an extremely poor
outcome. Approximately 80% of cases of this malignancy in Asian countries including India …

Drugging multiple same-allele driver mutations in cancer

R Nussinov, M Zhang, R Maloney… - Expert opinion on drug …, 2021 - Taylor & Francis
Analyses of cancer landscapes have established multiple activating mutations prompting
deliberations on the minimal number required for driving cancer [1]. These are likely to …

High infiltration of B cells in tertiary lymphoid structures, TCR oligoclonality, and neoantigens are part of esophageal squamous cell carcinoma microenvironment

LRC Barros, PT Souza-Santos… - Journal of Leucocyte …, 2020 - academic.oup.com
Esophageal squamous cell carcinoma (ESCA) exhibits high intratumoral molecular
heterogeneity posing a challenge to cancer therapy. Immune checkpoint blockade therapy …

Interplay between HMGA and TP53 in cell cycle control along tumor progression

N Meireles Da Costa, A Palumbo, M De Martino… - Cellular and Molecular …, 2021 - Springer
The high mobility group A (HMGA) proteins are found to be aberrantly expressed in several
tumors. Studies (in vitro and in vivo) have shown that HMGA protein overexpression has a …

Upper aerodigestive tract squamous cell carcinomas show distinct overall DNA methylation profiles and different molecular mechanisms behind WNT signaling …

SC Soares-Lima, H Mehanna, D Camuzi… - Cancers, 2021 - mdpi.com
Simple Summary Squamous cell carcinomas of the upper aerodigestive tract are highly
incident, lethal, and share the same epithelial lining of origin, risk factors and genetic …

Systematic profiling identifies PDLIM2 as a novel prognostic predictor for oesophageal squamous cell carcinoma (ESCC)

G Song, J Xu, L He, X Sun, R Xiong… - Journal of cellular …, 2019 - Wiley Online Library
Till now, no appropriate biomarkers for high‐risk population screening and prognosis
prediction have been identified for patients with oesophageal squamous cell carcinoma …

A natural WNT signaling variant potently synergizes with Cdkn2ab loss in skin carcinogenesis

P Krimpenfort, M Snoek, JP Lambooij, JY Song… - Nature …, 2019 - nature.com
Cdkn2ab knockout mice, generated from 129P2 ES cells develop skin carcinomas. Here we
show that the incidence of these carcinomas drops gradually in the course of backcrossing …

幽门螺杆菌与食管鳞状细胞癌相关性研究进展

庄铭泉, 肖沁阳, 林琳 - 大连医科大学学报, 2020 - journal.dmu.edu.cn
幽门螺杆菌被认为与消化性溃疡和胃癌等疾病相关, 最近也被发现可能与许多胃外疾病相关.
本综述通过在PubMed 上检索目前幽门螺杆菌与食管鳞状细胞癌相关性研究文献 …

[PDF][PDF] Thiago de Souza Santos P, et al

T de Almeida Simão, SC Soares Lima… - … is a prognosfic … - journalononcology.org
Abstract Esophageal Squamous Cell Carcinoma (ESCC) is a highly incident and fatal
disease and represents more than 90% of all esophageal cancer worldwide. It has a poor …

Avaliação dos níveis de expressão de genes HOX e potenciais mecanismos de regulação da expressão gênica em carcinoma epidermoide de esôfago

JV Gomes - 2021 - bdtd.uerj.br
Extração de RNA..................................................................................................... Quantificação do
RNA............................................................................................. Síntese de cDNA-Transcriptase …