Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

Changes in the properties and postsynaptic abundance of AMPA-type glutamate receptors
(AMPARs) are major mechanisms underlying various forms of synaptic plasticity, including …

Complement overactivation mediates microglial synapse elimination in neurological
diseases such as Alzheimer's disease (AD) and frontotemporal dementia (FTD), but how …

Gene transcription is the process by which the genetic codes of organisms are read and
interpreted as a set of instructions for cells to divide, differentiate, migrate, and mature. As …

In the hippocampus GABAergic local circuit inhibitory interneurons represent only~ 10–15%
of the total neuronal population; however, their remarkable anatomical and physiological …

AMPA receptors (AMPARs) are assemblies of four core subunits, GluA1–4, that mediate
most fast excitatory neurotransmission. The component subunits determine the functional …

AMPA receptors (AMPARs) are tetrameric ion channels that together with other ionotropic
glutamate receptors (iGluRs), the NMDA and kainate receptors, mediate a majority of …

Perineuronal nets (PNNs) are unique extracellular matrix structures that wrap around certain
neurons in the CNS during development and control plasticity in the adult CNS. They appear …

Alzheimer's disease (AD) is a neurodegenerative disease with heterogenous
pathophysiological changes that develop years before the onset of clinical symptoms. These …

The central nervous system (CNS) and the immune system are both intricate and highly
organized systems that regulate the entire body, with both sharing certain common features …