Elevated extracellular calcium ions promote proliferation and migration of mesenchymal stem cells via increasing osteopontin expression

MN Lee, HS Hwang, SH Oh, A Roshanzadeh… - … & molecular medicine, 2018 - nature.com
Supplementation of mesenchymal stem cells (MSCs) at sites of bone resorption is required
for bone homeostasis because of the non-proliferation and short lifespan properties of the …

Oscillatory fluid flow induces the osteogenic lineage commitment of mesenchymal stem cells: The effect of shear stress magnitude, frequency, and duration

E Stavenschi, MN Labour, DA Hoey - Journal of biomechanics, 2017 - Elsevier
A potent regulator of bone anabolism is physical loading. However, it is currently unclear
whether physical stimuli such as fluid shear within the marrow cavity is sufficient to directly …

CXCR1/Akt signaling activation induced by mesenchymal stem cell-derived IL-8 promotes osteosarcoma cell anoikis resistance and pulmonary metastasis

L Du, X Han, B Tu, M Wang, H Qiao, S Zhang… - Cell Death & …, 2018 - nature.com
The loss of appropriate cell adhesion normally induces apoptosis via a process termed
anoikis. The aim of this study was to investigate the effects of mesenchymal stem cells …

Granular PEG hydrogels mediate osteoporotic MSC clustering via N-cadherin influencing the pro-resorptive bias of their secretory profile

VV Rao, ME Wechsler, E Cravens, SJ Wojda… - Acta biomaterialia, 2022 - Elsevier
Postmenopausal osteoporosis results from a pro-resorptive bone environment, which
decreases bone mineral density causing increased fracture risk. Bone marrow derived …

TGFβ1–induced recruitment of human bone mesenchymal stem cells is mediated by the primary cilium in a SMAD3-dependent manner

MN Labour, M Riffault, ST Christensen, DA Hoey - Scientific reports, 2016 - nature.com
The recruitment of mesenchymal stem cells (MSCs) is a crucial process in the development,
maintenance and repair of tissues throughout the body. Transforming growth factor-β1 …

Post‐menopausal oestrogen deficiency induces osteoblast apoptosis via regulating HOTAIR/miRNA‐138 signalling and suppressing TIMP1 expression

SY Xu, P Shi, RM Zhou - Journal of cellular and molecular …, 2021 - Wiley Online Library
In this study, we aimed to explore the molecular mechanisms underlying the development of
osteoporosis in post‐menopausal females. Real‐time PCR was conducted to measure the …

[HTML][HTML] Systematic analysis of lncRNAs, miRNAs and mRNAs for the identification of biomarkers for osteoporosis in the mandible of ovariectomized mice

L Hao, J Fu, Y Tian, J Wu - International Journal of …, 2017 - spandidos-publications.com
Osteoporosis is a complex and multifactorial disease caused by an imbalance between
bone formation and resorption. Post‑menopausal women with endogenous estrogen …

A unique heterologous fibrin sealant (HFS) as a candidate biological scaffold for mesenchymal stem cells in osteoporotic rats

PR Orsi, FC Landim-Alvarenga, LA Justulin… - Stem Cell Research & …, 2017 - Springer
Background The injection of mesenchymal stem cells (MSCs) directly into the bone of
osteoporotic (OP) patients for rapid recovery has been studied worldwide. Scaffolds …

Effect of low‐level laser therapy and oxytocin on osteoporotic bone marrow‐derived mesenchymal stem cells

S Fallahnezhad, A Piryaei, H Darbandi… - Journal of cellular …, 2018 - Wiley Online Library
Postmenopausal osteoporosis (OP) is a major concern for public health. Low‐level laser
therapy (LLLT) has a positive effect on the health of bone marrow mesenchymal stem cells …

Pressure‐induced mesenchymal stem cell osteogenesis is dependent on intermediate filament remodeling

E Stavenschi, DA Hoey - The FASEB Journal, 2019 - Wiley Online Library
Macroscale loading of bone generates a complex local mechanical microenvironment that
drives osteogenesis and bone mechanoadaptation. One such mechanical stimulus …