The pathogenesis of psoriasis can be explained by dysregulation of immunological cell
function as well as keratinocyte proliferation/differentiation. Recently, the immunological …

Increased understanding of the biology of interleukin 17 (IL-17) has revealed that this
cytokine is a central player in immunity at the sites most exposed to microorganisms …

The complete assembly of each human chromosome is essential for understanding human
biology and evolution,. Here we use complementary long-read sequencing technologies to …

Current research has demonstrated that small cationic amphipathic peptides have strong
potential not only as antimicrobials, but also as antibiofilm agents, immune modulators, and …

A major contribution to the genome variability among individuals comes from deletions and
duplications—collectively termed copy number variations (CNVs)—which alter the diploid …

Genomic structural variants have long been implicated in phenotypic diversity and human
disease, but dissecting the mechanisms by which they exert their functional impact has …

Thousands of genomic segments appear to be present in widely varying copy numbers in
different human genomes. We developed ways to use increasingly abundant whole-genome …

Topical application of imiquimod (IMQ), a TLR7/8 ligand and potent immune activator, can
induce and exacerbate psoriasis, a chronic inflammatory skin disorder. Recently, a crucial …

Psoriasis is a common inflammatory skin disease involving interactions between
keratinocytes and immune cells that significantly affects the quality of life. It is characterized …

(WTCCC2) consortia is provided in the Supplementary Note online. Author Contributions
FC, ADB, CEMG, J. Kere., A. Reis, JNB and RCT oversaw cohort collection for both the …