C. elegans has a highly developed chemosensory system that enables it to detect a wide
variety of volatile (olfactory) and water-soluble (gustatory) cues associated with food …

Chemosensory neurons translate perception of external chemical cues, including odorants,
tastants, and pheromones, into information that drives attraction or avoidance motor …

A major challenge in neuroscience is to reliably activate individual neurons, particularly
those in deeper brain regions. Current optogenetic approaches require invasive surgical …

Discrimination between pathogenic and beneficial microbes is essential for host organism
immunity and homeostasis. Here, we show that chemosensory detection of two secondary …

One key to animal survival is the detection and avoidance of potentially harmful compounds
by their bitter taste. Variable numbers of taste 2 receptor genes expressed in the gustatory …

Huntington's disease (HD) is an incurable disease with progressive loss of neural function,
which is influenced by epigenetic, oxidative stress, metabolic, and nutritional factors …

Using sequence profile analysis and sequence-based structure predictions, we define a
previously unrecognized, widespread class of P-loop NTPases. The signal transduction …

A current challenge in neuroscience is to bridge the gaps between genes, proteins, neurons,
neural circuits, and behavior in a single animal model. The nematode Caenorhabditis …

C. elegans is widely used to dissect how neural circuits and genes generate behavior.
During locomotion, worms initiate backward movement to change locomotion direction …

Polymodal nociceptors detect noxious stimuli, including harsh touch, toxic chemicals and
extremes of heat and cold. The molecular mechanisms by which nociceptors are able to …