Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs
Over the last two decades, hydrogen sulfide (H2S) has emerged as an endogenous
regulator of a broad range of physiological functions. H2S belongs to the class of molecules …
regulator of a broad range of physiological functions. H2S belongs to the class of molecules …
The role of thiols in antioxidant systems
The sulfur biochemistry of the thiol group endows cysteines with a number of highly
specialized and unique features that enable them to serve a variety of different functions in …
specialized and unique features that enable them to serve a variety of different functions in …
Supersulphides provide airway protection in viral and chronic lung diseases
T Matsunaga, H Sano, K Takita, M Morita… - Nature …, 2023 - nature.com
Supersulphides are inorganic and organic sulphides with sulphur catenation with diverse
physiological functions. Their synthesis is mainly mediated by mitochondrial cysteinyl-tRNA …
physiological functions. Their synthesis is mainly mediated by mitochondrial cysteinyl-tRNA …
Chemical Biology of H2S Signaling through Persulfidation
MR Filipovic, J Zivanovic, B Alvarez… - Chemical …, 2018 - ACS Publications
Signaling by H2S is proposed to occur via persulfidation, a posttranslational modification of
cysteine residues (RSH) to persulfides (RSSH). Persulfidation provides a framework for …
cysteine residues (RSH) to persulfides (RSSH). Persulfidation provides a framework for …
Selective persulfide detection reveals evolutionarily conserved antiaging effects of S-sulfhydration
J Zivanovic, E Kouroussis, JB Kohl, B Adhikari… - Cell metabolism, 2019 - cell.com
Life on Earth emerged in a hydrogen sulfide (H 2 S)-rich environment eons ago and with it
protein persulfidation mediated by H 2 S evolved as a signaling mechanism. Protein …
protein persulfidation mediated by H 2 S evolved as a signaling mechanism. Protein …
[HTML][HTML] Effects of hydrogen sulfide on mitochondrial function and cellular bioenergetics
Hydrogen sulfide (H 2 S) was once considered to have only toxic properties, until it was
discovered to be an endogenous signaling molecule. The effects of H 2 S are dose …
discovered to be an endogenous signaling molecule. The effects of H 2 S are dose …
Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics
T Akaike, T Ida, FY Wei, M Nishida, Y Kumagai… - Nature …, 2017 - nature.com
Cysteine hydropersulfide (CysSSH) occurs in abundant quantities in various organisms, yet
little is known about its biosynthesis and physiological functions. Extensive persulfide …
little is known about its biosynthesis and physiological functions. Extensive persulfide …
A review of hydrogen sulfide synthesis, metabolism, and measurement: is modulation of hydrogen sulfide a novel therapeutic for cancer?
X Cao, L Ding, Z Xie, Y Yang, M Whiteman… - Antioxidants & redox …, 2019 - liebertpub.com
Abstract Significance: Hydrogen sulfide (H2S) has been recognized as the third gaseous
transmitter alongside nitric oxide and carbon monoxide. In the past decade, numerous …
transmitter alongside nitric oxide and carbon monoxide. In the past decade, numerous …
N-acetyl cysteine functions as a fast-acting antioxidant by triggering intracellular H2S and sulfane sulfur production
The cysteine prodrug N-acetyl cysteine (NAC) is widely used as a pharmacological
antioxidant and cytoprotectant. It has been reported to lower endogenous oxidant levels and …
antioxidant and cytoprotectant. It has been reported to lower endogenous oxidant levels and …
Regulators of the transsulfuration pathway
The transsulfuration pathway is a metabolic pathway where transfer of sulfur from
homocysteine to cysteine occurs. The pathway leads to the generation of several sulfur …
homocysteine to cysteine occurs. The pathway leads to the generation of several sulfur …