The renaissance of organo nitriles in organic synthesis

A Rakshit, HN Dhara, AK Sahoo… - Chemistry–An Asian …, 2022 - Wiley Online Library
In the arena of functional group‐oriented organic synthesis, nitrile or cyano functionality is of
immense importance. The presence of nucleophilic N‐atom, π‐coordinating ability of the …

Regioselective Access to 1,2,4-Triazole-Fused N-Heterocycle, Pyrrolo[1,2-a][1,2,4]triazolo[5,1-c]pyrazine, via Double Dehydrative Cyclizations

H Oh, H Kim, I Kim - The Journal of Organic Chemistry, 2023 - ACS Publications
A highly efficient and regioselective approach to a novel 1, 2, 4-triazole-fused N-heterocyclic
scaffold, pyrrolo [1, 2-a][1, 2, 4] triazolo [3, 4-c] pyrazine, was established by base-promoted …

Visible-light driven electron–donor–acceptor (EDA) complex-initiated synthesis of thio-functionalized pyridines

HN Dhara, A Rakshit, D Barik, K Ghosh… - Chemical …, 2023 - pubs.rsc.org
A visible/solar-light-induced electron–donor–acceptor (EDA)-aggregated/mediated radical
cyclization between (E)-2-(1, 3-diarylallylidene) malononitriles and thiophenols leads to poly …

Visible/solar-light-driven thiyl-radical-triggered synthesis of multi-substituted pyridines

AK Sahoo, A Rakshit, A Pan, HN Dhara… - Organic & Biomolecular …, 2023 - pubs.rsc.org
A light-triggered synthesis of thio-functionalized pyridines is demonstrated using γ-
ketodinitriles, thiols, and eosin Y as the photocatalyst. The reaction proceeds via the …

Transformable Transient Directing Group-Assisted C(sp2)–H Activation: Synthesis and Late-Stage Functionalizations of o-Alkenylanilines

B Das, A Dahiya, AK Sahoo… - The Journal of Organic …, 2022 - ACS Publications
The isocyanate group in aryl isocyanates serves as a transformable transient directing group
in a Ru (II)-catalyzed ortho olefination leading to o-alkenylanilines. In alcoholic solvents, aryl …

Organic Base-Promoted C–N-and C–O-Coupled Domino Cyclization Strategy: Syntheses of Oxazine-6-ones and 4-Pyrimidinols

AS Manna, R Nandi, T Ghosh, S Pal… - The Journal of …, 2024 - ACS Publications
Oxazine-6-one and 4-pyrimidinol are two important frameworks in pharmaceutical
production. Herein, we disclosed a simple, efficient, inexpensive organic base-promoted …

Functional characterization and substrate promiscuity analysis of UDP-glucose dehydrogenases from licorice (Glycyrrhiza uralensis)

Y Li, Y Sun, G Ren, D Jiang, C Liu - Journal of Molecular Structure, 2022 - Elsevier
Uridine diphosphate glucose dehydrogenase (UGDH) has a crucial role in the synthesis of
UDP-glucuronic acid (UDPGA), which is the important sugar donor in the glucuronosylation …

Cu‐promoted Access to 1, 4‐Diazine‐fused Isoindoles Through Concomitant Csp3‐N and Csp2‐N Bonds Formation Starting from Constrained N, O‐acetals

C Safi, M Othman, AM Lawson, J Moncol… - Advanced Synthesis & … - Wiley Online Library
Scarce dihydro‐1, 4‐diazinoisoindole framework bearing two points of diversity was
prepared through interesting cascade process based on concomitant Csp3‐N and Csp2‐N …

[PDF][PDF] Addition-elimination reactions of 2, 2-disubstituted malononitriles and α-aryl nitriles. Subsequent transformations.

JMR Mattalia - ARKIVOC: Online Journal of Organic Chemistry, 2023 - arkat-usa.org
This review focuses on addition-eliminations on the cyano group of 2, 2-disubstituted
malononitriles and α-aryl nitriles. Mechanistic insights and applications are provided. This …

Six-membered ring systems: pyridines and benzo derivatives

JC Badenock - Progress in Heterocyclic Chemistry, 2023 - Elsevier
The class of pyridines and their benzo derivatives maintain prominence in the synthetic
literature due to their versatility and chemical and biological properties. These scaffolds …