The CRISPR/Cas9 system is an RNA-based adaptive immune system in bacteria and
archaea. Various studies have shown that it is possible to target a wide range of human …

Simple Summary Cells respond to genotoxic stress through complex protein pathways
called DNA damage response (DDR). These mechanisms ensure the preservation of …

Aging is a complex process indicated by low energy levels, declined physiological activity,
stress induced loss of homeostasis leading to the risk of diseases and mortality. Recent …

Simple Summary Circular RNAs (circRNAs) are single-stranded RNA molecules that form a
covalently closed loop structure. They are characterized by distinct features and …

Osteosarcoma (OS) is the most common primary bone malignancy in children and
adolescents which has the survival rate of 20% in its advanced stages. Osteosarcomas are …

Abstract Aims Circular RNAs (circRNAs) are endogenous covalently closed non-coding
RNAs produced by reverse splicing of linear RNA. These molecules are highly expressed in …

It is becoming more and more apparent that many of the genetic alterations associated with
cancer are located in areas that do not encode proteins. lncRNAs are a class of RNAs that …

Accurate and integral cellular DNA replication is modulated by multiple replication‐
associated proteins, which is fundamental to preserve genome stability. Furthermore …

Radiation-induced skin wound/dermatitis is one of the common side effects of radiotherapy
or interventional radiobiology. Gingiva-derived mesenchymal stem cells (GMSCs) were …

DNA damage response (DDR) comprising DNA repair and cell-cycle checkpoint pathways,
is considered as a protective process that maintains the integrity of the genome. However …