Diagnosis and treatment of Merkel cell carcinoma: European consensus-based interdisciplinary guideline–Update 2022

ML Gauci, C Aristei, JC Becker, A Blom… - European Journal of …, 2022 - Elsevier
Merkel cell carcinoma (MCC) is a rare skin cancer, accounting for less than 1% of all
cutaneous malignancies. It is found predominantly in white populations and risk factors …

Merkel cell carcinoma

JC Becker, A Stang, JA DeCaprio, L Cerroni… - Nature reviews Disease …, 2017 - nature.com
Merkel cell carcinoma (MCC) is a rare but highly aggressive skin cancer with
neuroendocrine features. MCC pathogenesis is associated with either the presence of …

The biology and treatment of Merkel cell carcinoma: current understanding and research priorities

PW Harms, KL Harms, PS Moore… - Nature reviews Clinical …, 2018 - nature.com
Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer associated with
advanced age and immunosuppression. Over the past decade, an association has been …

Molecular pathogenesis of Merkel cell carcinoma

JA DeCaprio - Annual Review of Pathology: Mechanisms of …, 2021 - annualreviews.org
Merkel cell carcinoma (MCC) is an aggressive neuroendocrine carcinoma of the skin with
two distinct etiologies. Clonal integration of Merkel cell polyomavirus DNA into the tumor …

Biology and evolution of poorly differentiated neuroendocrine tumors

DS Rickman, H Beltran, F Demichelis, MA Rubin - Nature medicine, 2017 - nature.com
Neuroendocrine (NE) cancers are a diverse group of neoplasms typically diagnosed and
treated on the basis of their site of origin. This Perspective focuses on advances in our …

Merkel cell polyomavirus and Merkel cell carcinoma

V Pietropaolo, C Prezioso, U Moens - Cancers, 2020 - mdpi.com
Viruses are the cause of approximately 15% of all human cancers. Both RNA and DNA
human tumor viruses have been identified, with Merkel cell polyomavirus being the most …

Biology, evolution, and medical importance of polyomaviruses: An update

U Moens, A Krumbholz, B Ehlers, R Zell… - Infection, Genetics and …, 2017 - Elsevier
The family Polyomaviridae encompasses non-enveloped viruses with a circular dsDNA
genome that is typically approximately 5000 bp in length. Originally isolated from mammals …

Are there multiple cells of origin of Merkel cell carcinoma?

JC Sunshine, NS Jahchan, J Sage, J Choi - Oncogene, 2018 - nature.com
Merkel cell carcinoma (MCC) is a rare but lethal cancer with the highest case-by-case fatality
rate among all skin cancers. Eighty percent of cancers are associated with the Merkel cell …

Merkel cell polyomavirus recruits MYCL to the EP400 complex to promote oncogenesis

J Cheng, DE Park, C Berrios, EA White, R Arora… - PLoS …, 2017 - journals.plos.org
Merkel cell carcinoma (MCC) frequently contains integrated copies of Merkel cell
polyomavirus DNA that express a truncated form of Large T antigen (LT) and an intact Small …

Epidemiology, biology and therapy of Merkel cell carcinoma: conclusions from the EU project IMMOMEC

JC Becker, A Stang, A Hausen, N Fischer… - Cancer Immunology …, 2018 - Springer
Merkel cell carcinoma (MCC) is a highly aggressive, often lethal neuroendocrine cancer. Its
carcinogenesis may be either caused by the clonal integration of the Merkel cell …