Importance Cardiovascular disease and cancer are the 2 leading causes of death in the US,
and vitamin and mineral supplementation has been proposed to help prevent these …

Background Numerous studies demonstrate associations between serum concentrations of
25-hydroxyvitamin D (25 [OH] D) and a variety of common disorders, including …

Background Vitamin D supplements are widely recommended for bone health in the general
population, but data on whether they prevent fractures have been inconsistent. Methods In …

The etiology of endemic rickets was discovered a century ago. Vitamin D is the precursor of
25-hydroxyvitamin D and other metabolites, including 1, 25 (OH) 2D, the ligand for the …

Background It is unclear whether supplementation with vitamin D reduces the risk of cancer
or cardiovascular disease, and data from randomized trials are limited. Methods We …

Importance Vitamin D and calcium supplements are recommended for the prevention of
fracture, but previous randomized clinical trials (RCTs) have reported conflicting results, with …

Background The effects of vitamin D on fractures, falls, and bone mineral density are
uncertain, particularly for high vitamin D doses. We aimed to determine the effect of vitamin …

Importance Observational studies have reported an association between low serum vitamin
D levels and elevated risk of cardiovascular disease (CVD) events, but such studies cannot …

Importance The increased social and economic burdens for osteoporosis-related fractures
worldwide make the prevention of such injuries a major public health goal. Previous studies …

Background Previous meta-analyses of randomized controlled trials (RCTs) of vitamin D
supplementation and total cancer incidence and mortality found inconsistent results, and …