[HTML][HTML] Adult mammalian neural stem cells and neurogenesis: five decades later
Adult somatic stem cells in various organs maintain homeostatic tissue regeneration and
enhance plasticity. Since its initial discovery five decades ago, investigations of adult …
enhance plasticity. Since its initial discovery five decades ago, investigations of adult …
[HTML][HTML] The role of DNA methylation in epigenetics of aging
A Unnikrishnan, WM Freeman, J Jackson… - Pharmacology & …, 2019 - Elsevier
Recent research suggests that epigenetics, especially DNA methylation, plays a mechanistic
role in aging. Epigenetic clocks, which measure changes in a few hundred specific CpG …
role in aging. Epigenetic clocks, which measure changes in a few hundred specific CpG …
[HTML][HTML] Epitranscriptomic m6A regulation of axon regeneration in the adult mammalian nervous system
Summary N 6-methyladenosine (m 6 A) affects multiple aspects of mRNA metabolism and
regulates developmental transitions by promoting mRNA decay. Little is known about the …
regulates developmental transitions by promoting mRNA decay. Little is known about the …
[HTML][HTML] Is plasticity of synapses the mechanism of long-term memory storage?
WC Abraham, OD Jones, DL Glanzman - NPJ science of learning, 2019 - nature.com
It has been 70 years since Donald Hebb published his formalized theory of synaptic
adaptation during learning. Hebb's seminal work foreshadowed some of the great …
adaptation during learning. Hebb's seminal work foreshadowed some of the great …
Neuronal activity modifies the DNA methylation landscape in the adult brain
DNA methylation has been traditionally viewed as a highly stable epigenetic mark in
postmitotic cells. However, postnatal brains appear to show stimulus-induced methylation …
postmitotic cells. However, postnatal brains appear to show stimulus-induced methylation …
Neuronal activity modifies the chromatin accessibility landscape in the adult brain
Neuronal activity-induced gene expression modulates the function and plasticity of the
nervous system. It is unknown whether and to what extent neuronal activity may trigger …
nervous system. It is unknown whether and to what extent neuronal activity may trigger …
[HTML][HTML] Tet1 is critical for neuronal activity-regulated gene expression and memory extinction
The ten-eleven translocation (Tet) family of methylcytosine dioxygenases catalyze oxidation
of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) and promote DNA …
of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) and promote DNA …
[图书][B] The developing genome: An introduction to behavioral epigenetics
DS Moore - 2015 - books.google.com
Why do we grow up to look, act, and feel as we do? Through most of the twentieth century,
scientists and laypeople answered this question by referring to two factors alone: our …
scientists and laypeople answered this question by referring to two factors alone: our …
The effects of early life stress on the epigenome: from the womb to adulthood and even before
N Provençal, EB Binder - Experimental neurology, 2015 - Elsevier
Exposure to early life stress (ELS), such as childhood abuse and neglect is a well
established major risk factor for developing psychiatric and behavioral disorders later in life …
established major risk factor for developing psychiatric and behavioral disorders later in life …
[HTML][HTML] Epigenetic regulation and chromatin remodeling in learning and memory
S Kim, BK Kaang - Experimental & molecular medicine, 2017 - nature.com
Understanding the underlying mechanisms of memory formation and maintenance has been
a major goal in the field of neuroscience. Memory formation and maintenance are tightly …
a major goal in the field of neuroscience. Memory formation and maintenance are tightly …