Post-translational modifications (PTMs) on tau have long been recognized as affecting
protein function and contributing to neurodegeneration. The explosion of information on …

Targeting pathological tau protein in Alzheimer's disease (AD) and related tauopathies has
shown great potential in animal models. Given that tau lesions correlate better with the …

Aggregation and deposition of β-amyloid and/or tau protein are the key neuropathological
features in neurodegenerative disorders such as Alzheimer's disease (AD) and other …

One of the defining pathological features of Alzheimer disease (AD) is the intraneuronal
accumulation of tau. The tau that forms these accumulations is altered both …

MicroRNAs (miRNA) regulate fundamental biological processes, including neuronal
plasticity, stress response, and survival. Here, we describe a neuroprotective function of miR …

In Alzheimer's disease, the microtubule-associated protein tau dissociates from the neuronal
cytoskeleton and aggregates to form cytoplasmic inclusions. Although hyperphosphorylation …

Neuronal mitochondria dysfunction and neuroinflammation are two prominent pathological
features increasingly realized as important pathogenic mechanisms for neurodegenerative …

Alzheimer's disease (AD) is the most common (60% to 80%) age‐related disease
associated with dementia and is characterized by a deterioration of behavioral and cognitive …

A group of neurodegenerative diseases referred to as tauopathies are characterized by the
presence of brain cells harboring inclusions of pathological species of the tau protein. These …

Over recent years, accumulated evidence suggests that autophagy induction is protective in
animal models of a number of neurodegenerative diseases. Intense research in the field has …