Background: Our objectives were to (1) determine the pharmacokinetic indices of
vancomycin in pediatric patients; and (2) compare attainment of 2 target exposures: area …

Loop diuretics and antibiotics are commonly co-prescribed across many clinical care
settings. Loop diuretics may alter antibiotic pharmacokinetics (PK) via several potential drug …

Abstract Background and Objective The use of continuous renal replacement therapy
(CRRT) for renal support has increased substantially in critically ill children compared with …

Background: Congenital diaphragmatic hernia (CDH) often presents with severe cardio-
respiratory impairment in the neonatal period. Affected infants may be exposed to multiple …

OBJECTIVE Vancomycin is often used in the pediatric cardiac surgical population, but few
pharmacokinetic data are available to guide dosing. METHODS A retrospective, population …

Objective The objective of this study was to check which initial dose of vancomycin is
needed to achieve the therapeutic target that is currently used in pediatrics. Methods The …

Purpose The study aimed to perform a population pharmacokinetic (PK) analysis to obtain
vancomycin PK parameter estimates in Sudanese adult patients. The population PK model …

Objectives To describe the pharmacokinetics of vancomycin in a large Chinese paediatric
cohort with varying degrees of renal function and ages and to develop practical dosing …

Background: Pharmacokinetics (PK), pharmacodynamics and optimal dosing of vancomycin
in obese children is not known. Higher trough levels of vancomycin may improve outcomes …

OBJECTIVES: This study compared vancomycin trough concentrations and pharmacokinetic
parameters in pediatric cardiothoracic surgery (CTS) patients versus those in controls …