Entorhinal cortex dysfunction in Alzheimer's disease
KM Igarashi - Trends in neurosciences, 2023 - cell.com
The entorhinal cortex (EC) is the brain region that often exhibits the earliest histological
alterations in Alzheimer's disease (AD), including the formation of neurofibrillary tangles and …
alterations in Alzheimer's disease (AD), including the formation of neurofibrillary tangles and …
Dentate gyrus circuits for encoding, retrieval and discrimination of episodic memories
T Hainmueller, M Bartos - Nature Reviews Neuroscience, 2020 - nature.com
The dentate gyrus (DG) has a key role in hippocampal memory formation. Intriguingly, DG
lesions impair many, but not all, hippocampus-dependent mnemonic functions, indicating …
lesions impair many, but not all, hippocampus-dependent mnemonic functions, indicating …
Microglia use TAM receptors to detect and engulf amyloid β plaques
Y Huang, KE Happonen, PG Burrola, C O'Connor… - Nature …, 2021 - nature.com
Two microglial TAM receptor tyrosine kinases, Axl and Mer, have been linked to Alzheimer's
disease, but their roles in disease have not been tested experimentally. We find that in …
disease, but their roles in disease have not been tested experimentally. We find that in …
Engrams and circuits crucial for systems consolidation of a memory
Episodic memories initially require rapid synaptic plasticity within the hippocampus for their
formation and are gradually consolidated in neocortical networks for permanent storage …
formation and are gradually consolidated in neocortical networks for permanent storage …
Hippocampal sharp wave‐ripple: A cognitive biomarker for episodic memory and planning
G Buzsáki - Hippocampus, 2015 - Wiley Online Library
Sharp wave ripples (SPW‐Rs) represent the most synchronous population pattern in the
mammalian brain. Their excitatory output affects a wide area of the cortex and several …
mammalian brain. Their excitatory output affects a wide area of the cortex and several …
[HTML][HTML] Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model
K Clayton, JC Delpech, S Herron, N Iwahara… - Molecular …, 2021 - Springer
Background Recent studies suggest that microglia contribute to tau pathology progression in
Alzheimer's disease. Amyloid plaque accumulation transforms microglia, the primary innate …
Alzheimer's disease. Amyloid plaque accumulation transforms microglia, the primary innate …
Time cells in the hippocampus: a new dimension for mapping memories
H Eichenbaum - Nature Reviews Neuroscience, 2014 - nature.com
Recent studies have revealed the existence of hippocampal neurons that fire at successive
moments in temporally structured experiences. Several studies have shown that such …
moments in temporally structured experiences. Several studies have shown that such …
[HTML][HTML] Architecture of the entorhinal cortex a review of entorhinal anatomy in rodents with some comparative notes
MP Witter, TP Doan, B Jacobsen, ES Nilssen… - Frontiers in systems …, 2017 - frontiersin.org
The entorhinal cortex (EC) is the major input and output structure of the hippocampal
formation, forming the nodal point in cortico-hippocampal circuits. Different division schemes …
formation, forming the nodal point in cortico-hippocampal circuits. Different division schemes …
Ventral CA1 neurons store social memory
The medial temporal lobe, including the hippocampus, has been implicated in social
memory. However, it remains unknown which parts of these brain regions and their circuits …
memory. However, it remains unknown which parts of these brain regions and their circuits …
Dopamine facilitates associative memory encoding in the entorhinal cortex
Mounting evidence shows that dopamine in the striatum is critically involved in reward-
based reinforcement learning,. However, it remains unclear how dopamine reward signals …
based reinforcement learning,. However, it remains unclear how dopamine reward signals …