The entorhinal cortex (EC) is the brain region that often exhibits the earliest histological
alterations in Alzheimer's disease (AD), including the formation of neurofibrillary tangles and …

The dentate gyrus (DG) has a key role in hippocampal memory formation. Intriguingly, DG
lesions impair many, but not all, hippocampus-dependent mnemonic functions, indicating …

Two microglial TAM receptor tyrosine kinases, Axl and Mer, have been linked to Alzheimer's
disease, but their roles in disease have not been tested experimentally. We find that in …

Episodic memories initially require rapid synaptic plasticity within the hippocampus for their
formation and are gradually consolidated in neocortical networks for permanent storage …

Sharp wave ripples (SPW‐Rs) represent the most synchronous population pattern in the
mammalian brain. Their excitatory output affects a wide area of the cortex and several …

Background Recent studies suggest that microglia contribute to tau pathology progression in
Alzheimer's disease. Amyloid plaque accumulation transforms microglia, the primary innate …

Recent studies have revealed the existence of hippocampal neurons that fire at successive
moments in temporally structured experiences. Several studies have shown that such …

The entorhinal cortex (EC) is the major input and output structure of the hippocampal
formation, forming the nodal point in cortico-hippocampal circuits. Different division schemes …

The medial temporal lobe, including the hippocampus, has been implicated in social
memory. However, it remains unknown which parts of these brain regions and their circuits …

Mounting evidence shows that dopamine in the striatum is critically involved in reward-
based reinforcement learning,. However, it remains unclear how dopamine reward signals …