[HTML][HTML] Single nucleotide polymorphisms and cancer susceptibility
NA Deng, H Zhou, H Fan, Y Yuan - Oncotarget, 2017 - ncbi.nlm.nih.gov
A large number of genes associated with various cancer types contain single nucleotide
polymorphisms (SNPs). SNPs are located in gene promoters, exons, introns as well as 5' …
polymorphisms (SNPs). SNPs are located in gene promoters, exons, introns as well as 5' …
[HTML][HTML] DNA methylation and its basic function
LD Moore, T Le, G Fan - Neuropsychopharmacology, 2013 - nature.com
In the mammalian genome, DNA methylation is an epigenetic mechanism involving the
transfer of a methyl group onto the C5 position of the cytosine to form 5-methylcytosine. DNA …
transfer of a methyl group onto the C5 position of the cytosine to form 5-methylcytosine. DNA …
[HTML][HTML] Folate and DNA methylation: a review of molecular mechanisms and the evidence for folate's role
KS Crider, TP Yang, RJ Berry, LB Bailey - Advances in nutrition, 2012 - Elsevier
ABSTRACT DNA methylation is an epigenetic modification critical to normal genome
regulation and development. The vitamin folate is a key source of the one carbon group …
regulation and development. The vitamin folate is a key source of the one carbon group …
DNA methylation landscapes: provocative insights from epigenomics
MM Suzuki, A Bird - Nature reviews genetics, 2008 - nature.com
The genomes of many animals, plants and fungi are tagged by methylation of DNA cytosine.
To understand the biological significance of this epigenetic mark it is essential to know …
To understand the biological significance of this epigenetic mark it is essential to know …
[HTML][HTML] Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island context
Epigenetic control of gene transcription is critical for normal human development and
cellular differentiation. While alterations of epigenetic marks such as DNA methylation have …
cellular differentiation. While alterations of epigenetic marks such as DNA methylation have …
Cancer epigenomics: DNA methylomes and histone-modification maps
M Esteller - Nature reviews genetics, 2007 - nature.com
An altered pattern of epigenetic modifications is central to many common human diseases,
including cancer. Many studies have explored the mosaic patterns of DNA methylation and …
including cancer. Many studies have explored the mosaic patterns of DNA methylation and …
[HTML][HTML] The mammalian epigenome
BE Bernstein, A Meissner, ES Lander - Cell, 2007 - cell.com
Chemical modifications to DNA and histone proteins form a complex regulatory network that
modulates chromatin structure and genome function. The epigenome refers to the complete …
modulates chromatin structure and genome function. The epigenome refers to the complete …
Epigenome-wide association studies for common human diseases
VK Rakyan, TA Down, DJ Balding, S Beck - Nature Reviews Genetics, 2011 - nature.com
Despite the success of genome-wide association studies (GWASs) in identifying loci
associated with common diseases, a substantial proportion of the causality remains …
associated with common diseases, a substantial proportion of the causality remains …
Genome-wide epigenetic regulation by early-life trauma
B Labonté, M Suderman, G Maussion… - Archives of general …, 2012 - jamanetwork.com
Context Our genome adapts to environmental influences, in part through epigenetic
mechanisms, including DNA methylation. Variations in the quality of the early environment …
mechanisms, including DNA methylation. Variations in the quality of the early environment …
A genome-wide analysis of CpG dinucleotides in the human genome distinguishes two distinct classes of promoters
S Saxonov, P Berg, DL Brutlag - Proceedings of the …, 2006 - National Acad Sciences
A striking feature of the human genome is the dearth of CpG dinucleotides (CpGs)
interrupted occasionally by CpG islands (CGIs), regions with relatively high content of the …
interrupted occasionally by CpG islands (CGIs), regions with relatively high content of the …