Background Many high-throughput experiments compare two phenotypes such as disease
vs. healthy, with the goal of understanding the underlying biological phenomena …

Pathway analysis has become the first choice for gaining insight into the underlying biology
of differentially expressed genes and proteins, as it reduces complexity and has increased …

Recent studies of genomic variation associated with autism have suggested the existence of
extreme heterogeneity. Large-scale transcriptomics should complement these results to …

Functional analysis of large gene lists, derived in most cases from emerging high-throughput
genomic, proteomic and bioinformatics scanning approaches, is still a challenging and …

Motivation: High-throughput technologies such as DNA sequencing and microarrays have
created the need for automated annotation of large sets of genes, including whole genomes …

Abstract The DAVID Gene Functional Classification Tool http://david. abcc. ncifcrf. gov uses
a novel agglomeration algorithm to condense a list of genes or associated biological terms …

All tools in the DAVID Bioinformatics Resources aim to provide functional interpretation of
large lists of genes derived from genomic studies. The newly updated DAVID Bioinformatics …

GO:: TermFinder comprises a set of object-oriented Perl modules for accessing Gene
Ontology (GO) information and evaluating and visualizing the collective annotation of a list of …

Background The first generation of genome sequence assemblies and annotations have
had a significant impact upon our understanding of the biology of the sequenced species …

Alternative polyadenylation (APA) of mRNAs has emerged as an important mechanism for
post-transcriptional gene regulation in higher eukaryotes. Although microarrays have …