Newly endocytosed integral cell surface proteins are typically either directed for degradation
or subjected to recycling back to the plasma membrane. The sorting of integral cell surface …

The early endosome (EE), also known as the sorting endosome (SE) is a crucial station for
the sorting of cargoes, such as receptors and lipids, through the endocytic pathways. The …

Emerging findings disclose unexpected components of G protein-coupled receptor (GPCR)
signaling and cell biology. Select GPCRs exhibit classical signaling, that is restricted to cell …

Endosomes are dynamic intracellular compartments that control the sorting of a constant
stream of different transmembrane cargos either for ESCRT‐mediated degradation or for …

Following endocytosis into the endosomal network, integral membrane proteins undergo
sorting for lysosomal degradation or are retrieved and recycled back to the cell surface. Here …

Retromer is a multi-protein complex that recycles transmembrane cargo from endosomes to
the trans-Golgi network and the plasma membrane. Defects in retromer impair various …

The dopamine transporter (DAT) transports extracellular dopamine into the intracellular
space contributing to the regulation of dopamine neurotransmission. A reduction of DAT …

The N‐methyl‐D‐aspartate receptors (NMDARs) are ionotropic glutamate receptors that
mediate the flux of calcium (Ca2+) into the post‐synaptic compartment. Ca2+ influx …

Intricate relationships between endocytosis and cellular signaling, first recognized nearly 40
years ago through the study of tyrosine kinase growth factor receptors, are now known to …

The tubular endolysosomal network is a quality control system that ensures the proper
delivery of internalized receptors to specific subcellular destinations in order to maintain …