Organisms have cellular machinery that is focused on optimum utilization of resources to
maximize growth and survival depending on various environmental and developmental …

The mitochondrion plays wide-ranging roles in eukaryotic cell physiology. In pathogenic
fungi, this central metabolic organelle mediates a range of functions related to disease, from …

Morphological transitions and metabolic regulation are critical for the human fungal
pathogen Candida albicans to adapt to the changing host environment. In this study, we …

Filamentous cell growth is a vital property of fungal pathogens. The mechanisms of
filamentation in the emerging multidrug-resistant fungal pathogen Candida auris are poorly …

Mitochondria are essential for cell growth and survival of most fungal pathogens. Energy
(ATP) produced during oxidation/reduction reactions of the electron transport chain (ETC) …

Mitochondria are best known for their role in the production of ATP; however, recent
research implicates other mitochondrial functions in the virulence of human pathogenic …

Candida albicans is one of the most impactful fungal pathogens and the most common
cause of invasive candidiasis, which is associated with very high mortality rates. With the …

The amino sugar N-acetylglucosamine (GlcNAc) is increasingly recognized as an important
signaling molecule in addition to its well-known structural roles at the cell surface. In the …

Single-celled organisms have different strategies to sense and utilize nutrients in their ever-
changing environments. The opportunistic fungal pathogen Candida albicans is a common …

Efficient assimilation of alternative carbon sources in glucose-limited host niches is critical
for colonization of Candida albicans, a commensal yeast that frequently causes …