Stem cell homing is a multistep endogenous physiologic process that is also used by
exogenously administered hematopoietic stem and progenitor cells (HSPCs). This multistep …

Sphingolipids are a class of complex lipids containing a backbone of sphingoid bases,
namely the organic aliphatic amino alcohol sphingosine (Sph), that are essential …

Inflammation is a network of complex processes involving a variety of metabolic and
signaling pathways aiming at healing and repairing damage tissue, or fighting infection …

The mechanisms of hematopoietic progenitor cell egress and clinical mobilization are not
fully understood. Herein, we report that in vivo desensitization of Sphingosine-1-phosphate …

Lipid dysmetabolism is one of the main features of diabetes mellitus and manifests by
dyslipidemia as well as the ectopic accumulation of lipids in various tissues and organs …

Although chemotherapy is a conventional cancer treatment, it may induce a protumorigenic
microenvironment by triggering the release of proinflammatory mediators. In this study, we …

Background Mesenchymal stromal cells (MSC) are shown to have a great therapeutic
potential in many immunological disorders. Currently the therapeutic effect of MSCs is …

The bioactive sphingolipid ceramide 1-phosphate (C1P) regulates key physiologic cell
functions and is implicated in a number of metabolic alterations and pathological processes …

Sphingomyelin phosphodiesterase acid-like 3b (SMPDL3b) is a lipid raft enzyme that
regulates plasma membrane (PM) fluidity. Here we report that SMPDL3b excess, as …

Abstract Purpose of Review The goal of this review is to review the role that renal
parenchymal lipid accumulation plays in contributing to diabetic kidney disease (DKD) …