Iron metabolism in ferroptosis

X Chen, C Yu, R Kang, D Tang - Frontiers in cell and developmental …, 2020 - frontiersin.org
Ferroptosis is a form of regulated cell death that is characterized by iron-dependent
oxidative damage and subsequent plasma membrane ruptures and the release of damage …

Redox-and non-redox-metal-induced formation of free radicals and their role in human disease

M Valko, K Jomova, CJ Rhodes, K Kuča… - Archives of toxicology, 2016 - Springer
Transition metal ions are key elements of various biological processes ranging from oxygen
formation to hypoxia sensing, and therefore, their homeostasis is maintained within strict …

Lipocalin 2 expression promotes tumor progression and therapy resistance by inhibiting ferroptosis in colorectal cancer

N Chaudhary, BS Choudhary, SG Shah… - … Journal of Cancer, 2021 - Wiley Online Library
Lipocalin 2 is a siderophore‐binding protein that regulates iron homeostasis. Lipocalin 2
expression is elevated in multiple tumor types; however, the mechanisms that drive tumor …

Nutrients, foods, and colorectal cancer prevention

M Song, WS Garrett, AT Chan - Gastroenterology, 2015 - Elsevier
Diet has an important role in the development of colorectal cancer. In the past few decades,
findings from extensive epidemiologic and experimental investigations have linked …

Health effects and toxicity mechanisms of rare earth elements—Knowledge gaps and research prospects

G Pagano, M Guida, F Tommasi, R Oral - Ecotoxicology and environmental …, 2015 - Elsevier
In the recent decades, rare earth elements (REE) have undergone a steady spread in
several industrial and medical applications, and in agriculture. Relatively scarce information …

Advances in metal-induced oxidative stress and human disease

K Jomova, M Valko - Toxicology, 2011 - Elsevier
Detailed studies in the past two decades have shown that redox active metals like iron (Fe),
copper (Cu), chromium (Cr), cobalt (Co) and other metals undergo redox cycling reactions …

Superparamagnetic iron oxide nanoparticles: magnetic nanoplatforms as drug carriers

null Wahajuddin, S Arora - International journal of nanomedicine, 2012 - Taylor & Francis
A targeted drug delivery system is the need of the hour. Guiding magnetic iron oxide
nanoparticles with the help of an external magnetic field to its target is the principle behind …

A review on plant-based rutin extraction methods and its pharmacological activities

LS Chua - Journal of ethnopharmacology, 2013 - Elsevier
Ethnopharmacological relevance Rutin is a common dietary flavonoid that is widely
consumed from plant-derived beverages and foods as traditional and folkloric medicine …

Potential toxicity of superparamagnetic iron oxide nanoparticles (SPION)

N Singh, GJS Jenkins, R Asadi, SH Doak - Nano reviews, 2010 - Taylor & Francis
Superparamagnetic iron oxide nanoparticles (SPION) are being widely used for various
biomedical applications, for example, magnetic resonance imaging, targeted delivery of …

NanoGenotoxicology: the DNA damaging potential of engineered nanomaterials

N Singh, B Manshian, GJS Jenkins, SM Griffiths… - Biomaterials, 2009 - Elsevier
With the rapid expansion in the nanotechnology industry, it is essential that the safety of
engineered nanomaterials and the factors that influence their associated hazards are …