CD4+ T cells in cancer
Cancer immunology and immunotherapy are driving forces of research and development in
oncology, mostly focusing on CD8+ T cells and the tumor microenvironment. Recent …
oncology, mostly focusing on CD8+ T cells and the tumor microenvironment. Recent …
T cells in health and disease
L Sun, Y Su, A Jiao, X Wang, B Zhang - Signal transduction and …, 2023 - nature.com
T cells are crucial for immune functions to maintain health and prevent disease. T cell
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …
CD4+ T cell help in cancer immunology and immunotherapy
Cancer immunotherapy aims to promote the activity of cytotoxic T lymphocytes (CTLs) within
a tumour, assist the priming of tumour-specific CTLs in lymphoid organs and establish …
a tumour, assist the priming of tumour-specific CTLs in lymphoid organs and establish …
Dendritic cells revisited
M Cabeza-Cabrerizo, A Cardoso… - Annual review of …, 2021 - annualreviews.org
Dendritic cells (DCs) possess the ability to integrate information about their environment and
communicate it to other leukocytes, shaping adaptive and innate immunity. Over the years, a …
communicate it to other leukocytes, shaping adaptive and innate immunity. Over the years, a …
Antigen presentation by dendritic cells and their instruction of CD4+ T helper cell responses
KL Hilligan, F Ronchese - Cellular & molecular immunology, 2020 - nature.com
Dendritic cells are powerful antigen-presenting cells that are essential for the priming of T
cell responses. In addition to providing T-cell-receptor ligands and co-stimulatory molecules …
cell responses. In addition to providing T-cell-receptor ligands and co-stimulatory molecules …
A nanoadjuvant that dynamically coordinates innate immune stimuli activation enhances cancer immunotherapy and reduces immune cell exhaustion
SM Jin, YJ Yoo, HS Shin, S Kim, SN Lee… - Nature …, 2023 - nature.com
Although conventional innate immune stimuli contribute to immune activation, they induce
exhausted immune cells, resulting in suboptimal cancer immunotherapy. Here we suggest a …
exhausted immune cells, resulting in suboptimal cancer immunotherapy. Here we suggest a …
New insights into IL-12-mediated tumor suppression
S Tugues, SH Burkhard, I Ohs, M Vrohlings… - Cell Death & …, 2015 - nature.com
During the past two decades, interleukin-12 (IL-12) has emerged as one of the most potent
cytokines in mediating antitumor activity in a variety of preclinical models. Through …
cytokines in mediating antitumor activity in a variety of preclinical models. Through …
Interleukin 12: still a promising candidate for tumor immunotherapy?
W Lasek, R Zagożdżon, M Jakobisiak - Cancer Immunology …, 2014 - Springer
Abstract Interleukin 12 (IL-12) seemed to represent the ideal candidate for tumor
immunotherapy, due to its ability to activate both innate (NK cells) and adaptive (cytotoxic T …
immunotherapy, due to its ability to activate both innate (NK cells) and adaptive (cytotoxic T …
[HTML][HTML] Peripheral inflammatory biomarkers in Alzheimer's disease: a brief review
JC Park, SH Han, I Mook-Jung - BMB reports, 2020 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is a chronic neurodegenerative disease characterized by the
accumulation of amyloid plaques and neurofibrillary tangles in the brain. The AD …
accumulation of amyloid plaques and neurofibrillary tangles in the brain. The AD …
Dendritic cell subsets
Dendritic cells (DC) are professional antigen presenting cells comprising a variety of
subsets, as either resident or migrating cells, in lymphoid and non-lymphoid organs. In the …
subsets, as either resident or migrating cells, in lymphoid and non-lymphoid organs. In the …