Superoxide (O2) poses multiple threats, which are diminished by a family of
metalloenzymes, the superoxide dismutases. Among the damaging effects of O are direct …

The initial step in extravasation of neutrophils (polymorphonuclear leukocytes [PMNs]) to the
extravascular space is adherence to the endothelium. We examined the effect of oxidants on …

The biosynthetic heme precursor 5-aminolevulinic acid (5-ALA) is a generator of oxygen
radicals in vitro and possibly in vivo during pathologic situations of 5-ALA overload, for …

Protection by the flavonoids, quercetin and rutin, against tert-butylhydroperoxide (tert-BOOH)-
and menadione-induced DNA single strand breaks was investigated in Caco-2 cells. Both …

Menadione (MD; 2-methyl-1, 4-naphthoquinone), a redox cycling quinone was shown to
induce single (ss)-and double (ds)-strand DNA breaks in human MCF-7 cells. This DNA …

The nature and extent of menadione (MD)-induced DNA damage were explored using the
human breast cancer cell line MCF-7. Concentration-dependent single-strand (ss) and …

Обобщены литературные данные о роли окислительного стресса в процессе старения
организма. Отражена связь некоторых показателей свободнорадикальных процессов …

The ability of naphthoquinones to generate reactive oxygen species has been widely
exploited in studies of oxidative stress. However, excess superoxide dismutase and catalase …

A micro-tetrazolium assay was employed to evaluate vitamin C (VC), vitamin K3 (VK3) and
vitamin C/vitamin K3 combinations (VC VK 3) for their antitumor activity against eight human …

We have previously derived 2 V79 clones resistant to menadione (Md1 cells) and cadmium
(Cd1 cells), respectively. They both were shown to be cross-resistant to hydrogen peroxide …