For the past century, insulin injections have saved millions of lives, but glycemic instability is
still a persistent challenge for people with diabetes, leading to tremendous morbidity and …

Abstract Purpose of Review Novel 3D organoid culture techniques have enabled long-term
expansion of pancreatic tissue. This review comprehensively summarizes and evaluates the …

Astrocytes play essential roles in brain function by supporting synaptic connectivity and
associated circuits. How these roles are regulated by transcription factors is unknown …

NEUROD1 is a transcription factor that helps maintain a mature phenotype of pancreatic β
cells. Disruption of Neurod1 during pancreatic development causes severe neonatal …

The lacrimal gland (LG) secretes aqueous tears. Previous studies have provided insights
into the cell lineage relationships during tissue morphogenesis. However, little is known …

Organoids have become one of the fastest progressing and applied models in biological
and medical research, and various organoids have now been developed for most of the …

STUDY QUESTION Is there an (epi) genetic basis in patients with central precocious puberty
(CPP) associated with multiple anomalies that unmasks underlying mechanisms or reveals …

Numerous studies have characterized the existence of cell subtypes, along with their
corresponding transcriptional profiles, within the developing mouse pancreas. The upstream …

NEUROGENIN3+ (NEUROG3+) cells are considered to be pancreatic endocrine
progenitors. Our current knowledge on the molecular program of NEUROG3+ cells in …

Stem cell-derived β cells (SC-β cells) differentiated from stem cell-derived pancreatic
progenitor (PP) cells are promising tools for enabling normal glucose control of islet …