Current challenges and best-practice protocols for microbiome analysis
Analyzing the microbiome of diverse species and environments using next-generation
sequencing techniques has significantly enhanced our understanding on metabolic …
sequencing techniques has significantly enhanced our understanding on metabolic …
Recent advanced technologies for the characterization of xenobiotic-degrading microorganisms and microbial communities
S Mishra, Z Lin, S Pang, W Zhang, P Bhatt… - … in Bioengineering and …, 2021 - frontiersin.org
Global environmental contamination with a complex mixture of xenobiotics has become a
major environmental issue worldwide. Many xenobiotic compounds severely impact the …
major environmental issue worldwide. Many xenobiotic compounds severely impact the …
Single molecule real-time (SMRT) sequencing comes of age: applications and utilities for medical diagnostics
S Ardui, A Ameur, JR Vermeesch… - Nucleic acids …, 2018 - academic.oup.com
Short read massive parallel sequencing has emerged as a standard diagnostic tool in the
medical setting. However, short read technologies have inherent limitations such as GC …
medical setting. However, short read technologies have inherent limitations such as GC …
Next-generation sequencing and emerging technologies
Genetic sequencing technologies are evolving at a rapid pace with major implications for
research and clinical practice. In this review, the authors provide an updated overview of …
research and clinical practice. In this review, the authors provide an updated overview of …
Bioinformatics and computational tools for next-generation sequencing analysis in clinical genetics
Clinical genetics has an important role in the healthcare system to provide a definitive
diagnosis for many rare syndromes. It also can have an influence over genetics prevention …
diagnosis for many rare syndromes. It also can have an influence over genetics prevention …
GenASM: A high-performance, low-power approximate string matching acceleration framework for genome sequence analysis
Genome sequence analysis has enabled significant advancements in medical and scientific
areas such as personalized medicine, outbreak tracing, and the understanding of evolution …
areas such as personalized medicine, outbreak tracing, and the understanding of evolution …
The shared frameshift mutation landscape of microsatellite-unstable cancers suggests immunoediting during tumor evolution
A Ballhausen, MJ Przybilla, M Jendrusch… - Nature …, 2020 - nature.com
The immune system can recognize and attack cancer cells, especially those with a high load
of mutation-induced neoantigens. Such neoantigens are abundant in DNA mismatch repair …
of mutation-induced neoantigens. Such neoantigens are abundant in DNA mismatch repair …
Resolving the full spectrum of human genome variation using Linked-Reads
Large-scale population analyses coupled with advances in technology have demonstrated
that the human genome is more diverse than originally thought. To date, this diversity has …
that the human genome is more diverse than originally thought. To date, this diversity has …
Next generation sequencing methods for diagnosis of epilepsy syndromes
Epilepsy is a neurological disorder characterized by an increased predisposition for
seizures. Although this definition suggests that it is a single disorder, epilepsy encompasses …
seizures. Although this definition suggests that it is a single disorder, epilepsy encompasses …
Methodologies for transcript profiling using long-read technologies
S Oikonomopoulos, A Bayega, S Fahiminiya… - Frontiers in …, 2020 - frontiersin.org
RNA sequencing using next-generation sequencing technologies (NGS) is currently the
standard approach for gene expression profiling, particularly for large-scale high-throughput …
standard approach for gene expression profiling, particularly for large-scale high-throughput …