Alternative splicing as a source of phenotypic diversity
A major goal of evolutionary genetics is to understand the genetic processes that give rise to
phenotypic diversity in multicellular organisms. Alternative splicing generates multiple …
phenotypic diversity in multicellular organisms. Alternative splicing generates multiple …
[HTML][HTML] Gene regulation by long non-coding RNAs and its biological functions
Evidence accumulated over the past decade shows that long non-coding RNAs (lncRNAs)
are widely expressed and have key roles in gene regulation. Recent studies have begun to …
are widely expressed and have key roles in gene regulation. Recent studies have begun to …
Regulation of adult stem cell quiescence and its functions in the maintenance of tissue integrity
A de Morree, TA Rando - Nature Reviews Molecular Cell Biology, 2023 - nature.com
Adult stem cells are important for mammalian tissues, where they act as a cell reserve that
supports normal tissue turnover and can mount a regenerative response following acute …
supports normal tissue turnover and can mount a regenerative response following acute …
RNA sequencing: the teenage years
Over the past decade, RNA sequencing (RNA-seq) has become an indispensable tool for
transcriptome-wide analysis of differential gene expression and differential splicing of …
transcriptome-wide analysis of differential gene expression and differential splicing of …
Emerging cellular and molecular determinants of idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF), the most common form of idiopathic interstitial
pneumonia, is a progressive, irreversible, and typically lethal disease characterized by an …
pneumonia, is a progressive, irreversible, and typically lethal disease characterized by an …
RNA-binding proteins in tumor progression
H Qin, H Ni, Y Liu, Y Yuan, T Xi, X Li… - Journal of hematology & …, 2020 - Springer
RNA-binding protein (RBP) has a highly dynamic spatiotemporal regulation process and
important biological functions. They are critical to maintain the transcriptome through post …
important biological functions. They are critical to maintain the transcriptome through post …
VIRMA mediates preferential m6A mRNA methylation in 3′UTR and near stop codon and associates with alternative polyadenylation
Abstract N 6-methyladenosine (m6A) is enriched in 3′ untranslated region (3′ UTR) and
near stop codon of mature polyadenylated mRNAs in mammalian systems and has …
near stop codon of mature polyadenylated mRNAs in mammalian systems and has …
Long non-coding RNA (lncRNA) H19 in human cancer: From proliferation and metastasis to therapy
M Hashemi, MS Moosavi, HM Abed, M Dehghani… - Pharmacological …, 2022 - Elsevier
Initiation and development of cancer depend on multiple factors that mutations in genes and
epigenetic level can be considered as important drivers. Epigenetic factors include a large …
epigenetic level can be considered as important drivers. Epigenetic factors include a large …
Alternative cleavage and polyadenylation in health and disease
Most human genes have multiple sites at which RNA 3ʹ end cleavage and polyadenylation
can occur, enabling the expression of distinct transcript isoforms under different conditions …
can occur, enabling the expression of distinct transcript isoforms under different conditions …
Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are associated with
loss of nuclear transactive response DNA-binding protein 43 (TDP-43). Here we identify that …
loss of nuclear transactive response DNA-binding protein 43 (TDP-43). Here we identify that …