Drug repositioning and repurposing can enhance traditional drug development efforts and
could accelerate the identification of new treatments for individuals with Alzheimer disease …

Acetylcholinesterase (AChE) plays an important role in the pathogenesis of
neurodegenerative diseases by influencing the inflammatory response, apoptosis, oxidative …

Neural stem cells (NSC) transplantation is garnering considerable attention in the treatment
of neurodegenerative diseases that are associated with cognitive decline. Current methods …

In Alzheimer disease (AD), which is the most common cause of dementia, the underlying
disease pathology most probably precedes the onset of cognitive symptoms by many years …

Progression of brain ageing is influenced by a complex interaction of genetic and
environmental factors. Analysis of genetically modified animals with uniform genetic …

Over one-quarter of adult Americans are diagnosed with a mental illness like Major
Depressive Disorder (MDD), Post-Traumatic Stress Disorder (PTSD), schizophrenia, and …

Alzheimer disease (AD) is the leading cause of dementia among elderly. Currently, no
effective treatment is available for AD. Analysis of transgenic mouse models of AD has …

Adult neural stem cells (aNSCs) derived from the subventricular zone of the brain show
therapeutic effects in EAE, an animal model of the chronic inflammatory neurodegenerative …

The amyloid-beta (Aβ) peptide is the derivative of amyloid precursor protein (APP)
generated through sequential proteolytic processing by β-and γ-secretases. Excessive …

Stem cell therapies have been proposed as a treatment option for neurodegenerative
diseases, but the best stem cell source and therapeutic efficacy for neuroregeneration …