Brain iron is tightly regulated by a multitude of proteins to ensure homeostasis. Iron
dyshomeostasis has become a molecular signature associated with aging which is …

Alzheimer's disease (AD) is the most common cause of dementia worldwide. As advancing
age is the greatest risk factor for developing AD, the number of those afflicted is expected to …

Immunotherapy for Alzheimer's disease (AD) relies on antibodies directed against toxic
amyloid-beta peptide (Aβ), which circulate in the bloodstream and remove Aβ from the …

Amyloid plaques are primarily composed of extracellular aggregates of amyloid-β (Aβ)
peptide and are a pathological signature of Alzheimer's disease. However, the factors that …

Aβ plaques are one of the two lesions in the brain that define the neuropathological
diagnosis of Alzheimer's disease. Plaques are highly diverse structures; many of them …

The increasing number of mouse models of human disease used in biomedical research
applications has led to an enhanced interest in non‐invasive imaging of mice, eg using MRI …

Amyloid plaques are one of the pathological hallmarks of Alzheimer's disease (AD). The
visualization of amyloid plaques in the brain is important to monitor AD progression and to …

Background: Monitoring iron deposition became possible with new dedicated quantitative
MRI sequences. These sequences hold promise to determine the role of iron in Alzheimer's …

Abnormally high brain iron, resulting from the disrupted expression or function of proteins
involved in iron metabolism in the brain, is an initial cause of neuronal death in …

Amyloid-beta (Aβ) plays an important role in the pathogenesis of Alzheimer's disease.
Aberrant Aβ accumulation induces neuroinflammation, cerebrovascular alterations, and …