The roles and implications of RNA m6A modification in cancer
Abstract N 6-Methyladenosine (m6A), the most prevalent internal modification in eukaryotic
mRNA, has been extensively and increasingly studied over the past decade. Dysregulation …
mRNA, has been extensively and increasingly studied over the past decade. Dysregulation …
Hidden codes in mRNA: Control of gene expression by m6A
S Murakami, SR Jaffrey - Molecular cell, 2022 - cell.com
Information in mRNA has largely been thought to be confined to its nucleotide sequence.
However, the advent of mapping techniques to detect modified nucleotides has revealed …
However, the advent of mapping techniques to detect modified nucleotides has revealed …
RNA modifications: importance in immune cell biology and related diseases
L Cui, R Ma, J Cai, C Guo, Z Chen, L Yao… - Signal transduction and …, 2022 - nature.com
RNA modifications have become hot topics recently. By influencing RNA processes,
including generation, transportation, function, and metabolization, they act as critical …
including generation, transportation, function, and metabolization, they act as critical …
The proteins of mRNA modification: writers, readers, and erasers
MN Flamand, M Tegowski… - Annual review of …, 2023 - annualreviews.org
Over the past decade, mRNA modifications have emerged as important regulators of gene
expression control in cells. Fueled in large part by the development of tools for detecting …
expression control in cells. Fueled in large part by the development of tools for detecting …
m6A RNA methylation: from mechanisms to therapeutic potential
RNA carries a diverse array of chemical modifications that play important roles in the
regulation of gene expression. N 6‐methyladenosine (m6A), installed onto mRNA by the …
regulation of gene expression. N 6‐methyladenosine (m6A), installed onto mRNA by the …
The RNA m6A reader YTHDF2 maintains oncogene expression and is a targetable dependency in glioblastoma stem cells
Glioblastoma is a universally lethal cancer driven by glioblastoma stem cells (GSC). Here,
we interrogated N 6-methyladenosine (m6A) mRNA modifications in GSCs by methyl RNA …
we interrogated N 6-methyladenosine (m6A) mRNA modifications in GSCs by methyl RNA …
METTL3 regulates heterochromatin in mouse embryonic stem cells
Abstract METTL3 (methyltransferase-like 3) mediates the N 6-methyladenosine (m6A)
methylation of mRNA, which affects the stability of mRNA and its translation into protein …
methylation of mRNA, which affects the stability of mRNA and its translation into protein …
JNK Signaling Promotes Bladder Cancer Immune Escape by Regulating METTL3-Mediated m6A Modification of PD-L1 mRNA
Z Ni, P Sun, J Zheng, M Wu, C Yang, M Cheng, M Yin… - Cancer research, 2022 - AACR
The RNA N6-methyladenosine (m6A) writer methyltransferase-like 3 (METTL3) is
upregulated in many types of cancer and promotes cancer progression by increasing …
upregulated in many types of cancer and promotes cancer progression by increasing …
[HTML][HTML] Dynamic control of chromatin-associated m6A methylation regulates nascent RNA synthesis
Summary N 6-methyladenosine (m 6 A) methylation is co-transcriptionally deposited on
mRNA, but a possible role of m 6 A on transcription remains poorly understood. Here, we …
mRNA, but a possible role of m 6 A on transcription remains poorly understood. Here, we …
Inhibition of YTHDF2 triggers proteotoxic cell death in MYC-driven breast cancer
RNA-binding proteins (RBPs) are critical regulators of post-transcriptional gene expression,
and aberrant RBP-RNA interactions can promote cancer progression. Here, we interrogate …
and aberrant RBP-RNA interactions can promote cancer progression. Here, we interrogate …