Antimicrobial peptides (AMPs) take part in the immune system by mounting a first line of
defense against pathogens. Recurrent structural and functional aspects are observed …

General principles of protein structure, stability, and folding kinetics have recently been
explored in computer simulations of simple exact lattice models. These models represent …

Obtaining the correct balance of secondary structure propensities is a central priority in
protein force-field development. Given that current force fields differ significantly in their α …

Thermodynamic studies have demonstrated the central importance of a large negative heat
capacity change (Δ C° assoc) in site-specific protein-DNA recognition. Dissection of the …

To establish a framework for extrapolating the helix-forming properties of peptides from
TFE/H2O mixtures (TFE= 2, 2, 2-trifluoroethanol) back to water, the thermal unfolding curves …

Using an empirical analysis of experimental data we have estimated a set of energy
contributions which accounts for the stability of isolated α-helices. With this database and an …

In solution, biopolymers commonly fold into well-defined three-dimensional structures, but
only recently has analogous behavior been explored in synthetic chain molecules. An …

Helix propensities of the amino acids have been measured in alanine‐based peptides in the
absence of helix‐stabilizing side‐chain interactions. Fifty‐eight peptides have been studied …

Alpha-synuclein (αS) is a 140-amino-acid protein that is involved in a number of
neurodegenerative diseases. In Parkinson's disease, the protein is typically encountered in …

Among various alcohols, those substituted with fluorine, such as 2, 2, 2-trifluoroethanol
(TFE) or 3, 3, 3, 3 ', 3 ', 3 '-hexafluoro-2-propanol (HFIP), have a marked potential to induce …