Injury of articular cartilage due to trauma or pathological conditions is the major cause of
disability worldwide, especially in North America. The increasing number of patients …

Recent regenerative medicine and tissue engineering strategies for bone and cartilage
repair have led to fascinating progress of translation from basic research to clinical …

Introduction Transplantation of genetically modified human bone marrow-derived
mesenchymal stem cells (hMSCs) with an accurate potential for chondrogenic differentiation …

Controlling the phenotype of mesenchymal stem cells (MSCs) through the delivery of
regulatory genes is a promising strategy in tissue engineering (TE). Essential to effective …

Restoration of articular cartilage function and structure following pathological or traumatic
damage is still considered a challenging problem in the orthopaedic field. Currently, tissue …

Administration of mesenchymal stem cells (MSCs) that have a reliable potential for
chondrogenic differentiation is a promising approach currently employed to treat articular …

Recombinant adeno-associated virus (rAAV) vectors are clinically adapted vectors to
durably treat human osteoarthritis (OA). Controlled delivery of rAAV vectors via polymeric …

Background aims The aim of this study was to engineer sizable three-dimensional cartilage-
like constructs using stem cells isolated from human dental pulp stem cells (DPSCs) …

Recent advances in the approval and commercialization of gene therapeutics have fostered
the return of gene therapy to center stage. But despite new optimism, no Food and Drug …

To regenerate articular cartilage tissue from degeneration and trauma, synovial
mesenchymal stem cells (SMSCs) were used in this study as therapeutic progenitor cells to …