[HTML][HTML] Drug repurposing for next-generation combination therapies against multidrug-resistant bacteria

Y Liu, Z Tong, J Shi, R Li, M Upton, Z Wang - Theranostics, 2021 - ncbi.nlm.nih.gov
Antimicrobial resistance has been a global health challenge that threatens our ability to
control and treat life-threatening bacterial infections. Despite ongoing efforts to identify new …

[HTML][HTML] Virulence alterations in staphylococcus aureus upon treatment with the sub-inhibitory concentrations of antibiotics

J Chen, H Zhou, J Huang, R Zhang, X Rao - Journal of advanced research, 2021 - Elsevier
Background The treatment of patients with Staphylococcus aureus infections mainly relies
on antistaphylococcal regimens that are established with effective antibiotics. In antibiotic …

Subinhibitory Concentrations of Mupirocin Stimulate Staphylococcus aureus Biofilm Formation by Upregulating cidA

Y Jin, Y Guo, Q Zhan, Y Shang, D Qu… - Antimicrobial Agents and …, 2020 - Am Soc Microbiol
Previous studies have shown that the administration of antibiotics at subinhibitory
concentrations stimulates biofilm formation by the majority of multidrug-resistant …

Staphylococcus aureus lipoproteins in infectious diseases

M Mohammad, A Ali, MT Nguyen, F Götz… - Frontiers in …, 2022 - frontiersin.org
Infections with the Gram-positive bacterial pathogen Staphylococcus aureus remain a major
challenge for the healthcare system and demand new treatment options. The increasing …

Temperature-dependent carrier state mediated by H-NS promotes the long-term coexistence of Y. pestis and a phage in soil

L Yang, J Wang, S Lu, Y Zhong, K Xiong, X Liu… - PLoS …, 2023 - journals.plos.org
The study of carrier state phages challenged the canonical lytic-lysogenic binary, and carrier
state appears to be ubiquitous and ecologically important. However, the mechanisms of the …

A rapid, high‐yield and bioinspired synthesis of colloidal silver nanoparticles using Glycyrrhiza glabra root extract and assessment of antibacterial and …

M Kim, JS Sung, R Atchudan, A Syed… - Microscopy …, 2023 - Wiley Online Library
Silver nanoparticles (AgNPs) have emerged as highly effective antimicrobial agents against
multidrug‐resistant (MDR) pathogens. This study aims to employ green chemistry principles …

Bactericidal properties of rod-, peanut-, and star-shaped gold nanoparticles coated with ceragenin CSA-131 against multidrug-resistant bacterial strains

SJ Chmielewska, K Skłodowski, J Depciuch, P Deptuła… - Pharmaceutics, 2021 - mdpi.com
Background: The ever-growing number of infections caused by multidrug-resistant (MDR)
bacterial strains requires an increased effort to develop new antibiotics. Herein, we …

Inherently Reduced Expression of ASC Restricts Caspase-1 Processing in Hepatocytes and Promotes Plasmodium Infection

C Marques-da-Silva, C Schmidt-Silva… - The Journal of …, 2024 - journals.aai.org
Inflammasome-mediated caspase-1 activation facilitates innate immune control of
Plasmodium in the liver, thereby limiting the incidence and severity of clinical malaria …

Treatment of Bacterial Infections with β-Lactams: Cooperation with Innate Immunity

M Mondemé, C Carnoy, JC Sirard… - Infection and …, 2023 - Am Soc Microbiol
ABSTRACT β-Lactams are the most widely prescribed antibiotics used for the control and
treatment of bacterial infections. The direct effect of β-lactams on bacteria is well studied …

“Gene accordions” cause genotypic and phenotypic heterogeneity in clonal populations of Staphylococcus aureus

D Belikova, A Jochim, J Power, MTG Holden… - Nature …, 2020 - nature.com
Gene tandem amplifications are thought to drive bacterial evolution, but they are transient in
the absence of selection, making their investigation challenging. Here, we analyze genomic …