Intersectin—many facets of a scaffold protein
M Mintoo, V Rajagopalan… - Biochemical Society …, 2024 - portlandpress.com
Intersectin (ITSN) is a multi-domain scaffold protein with a diverse array of functions
including regulation of endocytosis, vesicle transport, and activation of various signal …
including regulation of endocytosis, vesicle transport, and activation of various signal …
ITSN1: a novel candidate gene involved in autosomal dominant neurodevelopmental disorder spectrum
ITSN1 plays an important role in brain development. Recent studies in large cohorts of
subjects with neurodevelopmental disorders have identified de novo variants in ITSN1 gene …
subjects with neurodevelopmental disorders have identified de novo variants in ITSN1 gene …
The LMP2A protein of Epstein–Barr virus regulates phosphorylation of ITSN1 and Shb adaptors by tyrosine kinases
Latent Membrane Protein 2A (LMP2A) is an Epstein–Barr virus-encoded protein that is
important for the maintenance of latent infection. Its activity affects cellular differentiation …
important for the maintenance of latent infection. Its activity affects cellular differentiation …
Adaptor proteins intersectin 1 and 2 bind similar proline-rich ligands but are differentially recognized by SH2 domain-containing proteins
Background Scaffolding proteins of the intersectin (ITSN) family, ITSN1 and ITSN2, are
crucial for the initiation stage of clathrin-mediated endocytosis. These proteins are closely …
crucial for the initiation stage of clathrin-mediated endocytosis. These proteins are closely …
Intersectin-1s deficiency in pulmonary pathogenesis
N Jeganathan, D Predescu, S Predescu - Respiratory Research, 2017 - Springer
Abstract Intersectin-1s (ITSN-1s), a multidomain adaptor protein, plays a vital role in
endocytosis, cytoskeleton rearrangement and cell signaling. Recent studies have …
endocytosis, cytoskeleton rearrangement and cell signaling. Recent studies have …
Amphiphysin 1 and 2 interact with latent membrane protein 2A of Epstein-Barr virus and regulate its exosomal secretion
Latent membrane protein 2A (LMP2A) of Epstein-Barr virusisimplicated in the regulation of
viral latency. The aim of the current study was to identify proteins interacting with proline-rich …
viral latency. The aim of the current study was to identify proteins interacting with proline-rich …
[PDF][PDF] ITSN protein family: regulation of diversity, role in signalling and pathology
Adaptor/scaffold proteins of the intersectin (ITSN) family are important components of
endocytic and signalling complexes. They coordinate trafficking events with actin …
endocytic and signalling complexes. They coordinate trafficking events with actin …
Transcriptional and posttranscriptional regulation of the adaptor/scaffold protein gene ITSN1
SV Kropyvko, OS Gubar, TA Gryaznova… - Biopolymers and …, 2016 - irbis-nbuv.gov.ua
ITSN1 adaptor/scaffold protein takes part in a variety of physiological and pathological
cellular processes. It has a complex expression regulation and many protein partners. Aim …
cellular processes. It has a complex expression regulation and many protein partners. Aim …
Ubiquitin‐ligase AIP 4 controls differential ubiquitination and stability of isoforms of the scaffold protein ITSN 1
At present, the role of ubiquitination of cargoes internalized from the plasma membrane is
better understood than the consequences of ubiquitination of proteins comprising the …
better understood than the consequences of ubiquitination of proteins comprising the …
[PDF][PDF] RTK signaling regulator SPRY2 associates with endocytic adaptor ITSN1 in vivo
Aim. Mitogenic signaling from RTK (receptor tyrosine kinase) is tightly linked to endocytosis
that regulates the fidelity of signal transduction. Intersectin 1 (ITSN1) is an evolutionarily …
that regulates the fidelity of signal transduction. Intersectin 1 (ITSN1) is an evolutionarily …