Oxidative stress in diabetes: implications for vascular and other complications

D Pitocco, M Tesauro, R Alessandro… - International journal of …, 2013 - mdpi.com
In recent decades, oxidative stress has become a focus of interest in most biomedical
disciplines and many types of clinical research. Increasing evidence shows that oxidative …

Oxidative stress and diabetic retinopathy: development and treatment

GD Calderon, OH Juarez, GE Hernandez, SM Punzo… - Eye, 2017 - nature.com
Diabetic retinopathy (DR) is the most common microvascular complication in diabetic
patients and one of the main causes of acquired blindness in the world. From the 90s until …

[HTML][HTML] Role of oxidative stress, inflammation, hypoxia and angiogenesis in the development of diabetic retinopathy

AS Al-Kharashi - Saudi journal of ophthalmology, 2018 - Elsevier
Diabetic retinopathy (DR) is a retinal disease which is one of the most severe complications
occuring due to diabetes mellitus and is a major cause of blindness. Patients who have …

The role of lipoxidation in the pathogenesis of diabetic retinopathy

J Augustine, EP Troendle, P Barabas… - Frontiers in …, 2021 - frontiersin.org
Lipids can undergo modification as a result of interaction with reactive oxygen species
(ROS). For example, lipid peroxidation results in the production of a wide variety of highly …

Docosahexaenoic acid alleviates oxidative stress-based apoptosis via improving mitochondrial dynamics in early brain injury after subarachnoid hemorrhage

T Zhang, P Wu, JH Zhang, Y Li, S Xu, C Wang… - Cellular and molecular …, 2018 - Springer
Mitochondrial dysfunction is considered a crucial therapeutic target for early brain injury
following subarachnoid hemorrhage (SAH). Emerging evidence indicates that …

Nitric oxide in the pathophysiology of retinopathy: evidences from preclinical and clinical researches

R Opatrilova, P Kubatka, M Caprnda… - Acta …, 2018 - Wiley Online Library
Retinopathy is the leading cause of blindness and visual disability in working‐aged people.
The pathogenesis of retinopathy is an actual and still open query. Alterations contributing to …

Understanding neurodegeneration from a clinical and therapeutic perspective in early diabetic retinopathy

S Fragiotta, MD Pinazo-Durán, G Scuderi - Nutrients, 2022 - mdpi.com
Recent evidence indicates that neurodegeneration is a critical element of diabetic
retinopathy (DR) pathogenesis. The neuronal cells' apoptosis contributes to microvascular …

Protective role of vitamin D against oxidative stress in diabetic retinopathy

MS Valle, C Russo… - … /metabolism research and …, 2021 - Wiley Online Library
Diabetic retinopathy (DR) is a microvascular complication of diabetes mellitus. There is
much evidence showing that a high level of mitochondrial overproduction of reactive oxygen …

[HTML][HTML] Inflammatory mediators in diabetic retinopathy: Deriving clinicopathological correlations for potential targeted therapy

A Sheemar, D Soni, B Takkar, S Basu… - Indian Journal of …, 2021 - journals.lww.com
The role of inflammation in diabetic retinopathy (DR) is well-established and dysregulation
of a large number of inflammatory mediators is known. These include cytokines …

Lipid peroxidation is associated with poor control of type-2 diabetes mellitus

SH Fatani, AT Babakr, EEM NourEldin… - Diabetes & Metabolic …, 2016 - Elsevier
Background Hyperglycemia increases oxidative stress through the overproduction of
reactive oxygen species, which results in an imbalance between free radicals and the …