Mass spectrometry of nucleic acid noncovalent complexes
Nucleic acids have been among the first targets for antitumor drugs and antibiotics. With the
unveiling of new biological roles in regulation of gene expression, specific DNA and RNA …
unveiling of new biological roles in regulation of gene expression, specific DNA and RNA …
Recent developments in the synthesis of azaindoles from pyridine and pyrrole building blocks
DR Motati, R Amaradhi, T Ganesh - Organic Chemistry Frontiers, 2021 - pubs.rsc.org
The azaindole chemical scaffold is represented in many biologically active natural products
and synthetic derivatives. Recently, this chemical scaffold yielded several therapeutic agents …
and synthetic derivatives. Recently, this chemical scaffold yielded several therapeutic agents …
New bio-sensitive and biologically active single crystal of pyrimidine scaffold ligand and its gold and platinum complexes: DFT, antimicrobial, antioxidant, DNA …
Novel gold and platinum complexes [AuL 2]· Cl, 1 and [PtL 2]· 2Cl, 2 with ligand, 2-methoxy-
6-((2-(4-(trifluoromethyl) pyrimidin-2-yl) hydrazono) methyl) phenol (HL) have been …
6-((2-(4-(trifluoromethyl) pyrimidin-2-yl) hydrazono) methyl) phenol (HL) have been …
Crystal structure, optical properties, DFT analysis of new morpholine based Schiff base ligands and their copper (II) complexes: DNA, protein docking analyses …
New morpholine derived Schiff base ligands (HL 1 and HL 2) and their Cu (II) complexes
[Cu (L 1) 2](1) and [Cu (L 2) 2](2) have been synthesized and characterized by 1 H NMR, IR …
[Cu (L 1) 2](1) and [Cu (L 2) 2](2) have been synthesized and characterized by 1 H NMR, IR …
Interface of G-quadruplex with both stabilizing and destabilizing ligands for targeting various diseases
S Chaudhary, M Kumar, M Kaushik - International Journal of Biological …, 2022 - Elsevier
Guanine-rich DNA sequences may fold back into non-canonical four-stranded secondary
structures termed as G-quadruplexes. The role of G-quadruplexes has already been well …
structures termed as G-quadruplexes. The role of G-quadruplexes has already been well …
Copper (II) salen-based complexes as potential anticancer agents
In this work, we have systematically designed and synthesized four Cu (II) salen compounds
(1–4), which have been characterized using various spectroscopic and analytical …
(1–4), which have been characterized using various spectroscopic and analytical …
Ionic liquid: an efficient and recyclable medium for the synthesis of fused six-membered oxygen heterocycles
N Kaur - Synthetic Communications, 2019 - Taylor & Francis
The investigation for replacement of organic solvents in chemical synthesis is a growing
area of interest due to increasing environmental issues. The use of ionic liquid salts as …
area of interest due to increasing environmental issues. The use of ionic liquid salts as …
Catalyst free, C-3 functionalization of imidazo [1, 2-a] pyridines to rapidly access new chemical space for drug discovery efforts
Multicomponent reactions (MCRs) are robust tools for the rapid synthesis of complex, small
molecule libraries for use in drug discovery and development. By utilizing MCR chemistry …
molecule libraries for use in drug discovery and development. By utilizing MCR chemistry …
Design, synthesis and biological evaluation of 3-(2-aminooxazol-5-yl)-2H-chromen-2-one derivatives
Background In view of wide range of biological activities of oxazole, a new series of oxazole
analogues was synthesized and its chemical structures were confirmed by spectral data …
analogues was synthesized and its chemical structures were confirmed by spectral data …
Oncogene expression modulation in cancer cell lines by DNA G-quadruplex-interactive small molecules
AP Francisco, A Paulo - Current medicinal chemistry, 2017 - ingentaconnect.com
Nucleic acids are prone to structural polymorphism and a number of structures may be
formed in addition to the well-known DNA double helix. Among these is a family of nucleic …
formed in addition to the well-known DNA double helix. Among these is a family of nucleic …