Tumor-associated macrophages are an abundant cell type in the tumor microenvironment.
These macrophages serve as a promising target for treatment of cancer due to their roles in …

The TYRO3, AXL (also known as UFO) and MERTK (TAM) family of receptor tyrosine
kinases (RTKs) are aberrantly expressed in multiple haematological and epithelial …

Tyrosine kinase inhibitors (TKIs)-treatments bring significant benefit for patients harboring
epidermal growth factor receptor (EGFR) mutations, especially for those with lung cancer …

Lung cancer is the deadliest malignancy worldwide. An inflammatory microenvironment is a
key factor contributing to lung tumor progression. Tumor-Associated Macrophages (TAMs) …

Novel treatment approaches are needed to overcome innate and acquired mechanisms of
resistance to current anticancer therapies in cancer cells and the tumour immune …

Growth arrest-specific 6, also known as Gas6, is a human gene encoding the Gas6 protein,
which was originally found to be upregulated in growth-arrested fibroblasts. Gas6 is a …

The AXL receptor tyrosine kinase and its major ligand, GAS6 have been demonstrated to be
overexpressed and activated in many human cancers (such as lung, breast, and pancreatic …

Pancreatic ductal adenocarcinoma is a highly metastatic disease and macrophages support
liver metastases. Efferocytosis, or engulfment of apoptotic cells by macrophages, is an …

The EGFR antibody cetuximab is used to treat numerous cancers, but intrinsic and acquired
resistance to this agent is a common clinical outcome. In this study, we show that …

The control of cellular growth and proliferation is key to the maintenance of homeostasis.
Survival, proliferation, and arrest are regulated, in part, by Growth Arrest Specific 6 (Gas6) …