Although anxiety disorders represent a major societal problem demanding new therapeutic
targets, these efforts have languished in the absence of a mechanistic understanding of this …

Apathy is a debilitating syndrome associated with many neurological disorders, including
several common neurodegenerative diseases such as Parkinson's disease and Alzheimer's …

Cognitive effort has been implicated in numerous theories regarding normal and aberrant
behavior and the physiological response to engagement with demanding tasks. Yet, despite …

Nucleus accumbens dopamine is known to play a role in motivational processes, and
dysfunctions of mesolimbic dopamine may contribute to motivational symptoms of …

Motivational and motor deficits are common in patients with depression and other psychiatric
disorders, and are related to symptoms of anhedonia and motor retardation. These deficits in …

Motivation determines multiple aspects of behavior, including action selection and
energization of behavior. Several components of the underlying neural systems have been …

Motivation has been defined as the process that allows organisms to regulate their internal
and external environment, and control the probability, proximity and availability of stimuli. As …

Recent years have seen a rejuvenation of interest in studies of motivation–cognition
interactions arising from many different areas of psychology and neuroscience. The present …

Anhedonia is a core symptom of major depressive disorder (MDD), the neurobiological
mechanisms of which remain poorly understood. Despite decades of speculation regarding …

As the global population ages, older decision makers will be required to take greater
responsibility for their own physical, psychological and financial well-being. With this in …