Complement in human disease: approved and up-and-coming therapeutics

EE West, T Woodruff, V Fremeaux-Bacchi, C Kemper - The Lancet, 2023 - thelancet.com
The complement system is recognised as a protector against blood-borne pathogens and a
controller of immune system and tissue homoeostasis. However, dysregulated complement …

[HTML][HTML] Cyclic peptides in pipeline: what future for these great molecules?

L Costa, E Sousa, C Fernandes - Pharmaceuticals, 2023 - mdpi.com
Cyclic peptides are molecules that are already used as drugs in therapies approved for
various pharmacological activities, for example, as antibiotics, antifungals, anticancer, and …

Guideline for the management of myasthenic syndromes

H Wiendl, A Abicht, A Chan… - Therapeutic …, 2023 - journals.sagepub.com
Myasthenia gravis (MG), Lambert-Eaton myasthenic syndrome (LEMS), and congenital
myasthenic syndromes (CMS) represent an etiologically heterogeneous group of (very) rare …

[HTML][HTML] Zilucoplan, a macrocyclic peptide inhibitor of human complement component 5, uses a dual mode of action to prevent terminal complement pathway …

GQ Tang, Y Tang, K Dhamnaskar, MD Hoarty… - Frontiers in …, 2023 - frontiersin.org
Introduction The complement system is a key component of the innate immune system, and
its aberrant activation underlies the pathophysiology of various diseases. Zilucoplan is a …

Myasthenia gravis: the changing treatment landscape in the era of molecular therapies

R Iorio - Nature Reviews Neurology, 2024 - nature.com
Myasthenia gravis (MG) is an autoimmune disorder that affects the neuromuscular junction,
leading to muscle weakness and fatigue. MG is caused by antibodies against the …

The ClC-1 chloride channel inhibitor NMD670 improves skeletal muscle function in rat models and patients with myasthenia gravis

M Skov, TQ Ruijs, TS Grønnebæk, M Skals… - Science translational …, 2024 - science.org
Myasthenia gravis (MG) is a neuromuscular disease that results in compromised
transmission of electrical signals at the neuromuscular junction (NMJ) from motor neurons to …

Generalized myasthenia gravis with acetylcholine receptor antibodies: A guidance for treatment

NE Gilhus, H Andersen, LK Andersen… - European Journal of …, 2024 - Wiley Online Library
Background Generalized myasthenia gravis (MG) with antibodies against the acetylcholine
receptor is a chronic disease causing muscle weakness. Access to novel treatments …

Therapeutic approach to autoimmune neurologic disorders

SL Clardy, TL Smith - CONTINUUM: Lifelong Learning in …, 2024 - journals.lww.com
OBJECTIVE Autoimmune neurologic disorders encompass a broad category of diseases
characterized by immune system attack of the central, peripheral, or autonomic nervous …

Current drug treatment of myasthenia gravis

F Vanoli, R Mantegazza - Current Opinion in Neurology, 2023 - journals.lww.com
Current drug treatment of myasthenia gravis : Current Opinion in Neurology Current drug
treatment of myasthenia gravis : Current Opinion in Neurology Log in or Register Subscribe to …

α-synuclein seed amplification and its uses in Parkinson's disease

D Berg, C Klein - The Lancet Neurology, 2023 - thelancet.com
Comment 370 www. thelancet. com/neurology Vol 22 May 2023 in the prodromal phase.
Third, demonstrate target engagement to identify treatment outcome objectively and enable …