The integrated brain network that controls respiration

F Krohn, M Novello, RS van der Giessen, CI De Zeeuw… - Elife, 2023 - elifesciences.org
Respiration is a brain function on which our lives essentially depend. Control of respiration
ensures that the frequency and depth of breathing adapt continuously to metabolic needs. In …

Diversity and dynamism in the cerebellum

CI De Zeeuw, SG Lisberger, JL Raymond - Nature neuroscience, 2021 - nature.com
The past several years have brought revelations and paradigm shifts in research on the
cerebellum. Historically viewed as a simple sensorimotor controller with homogeneous …

Polyglutamine spinocerebellar ataxias—from genes to potential treatments

HL Paulson, VG Shakkottai, HB Clark… - Nature Reviews …, 2017 - nature.com
The dominantly inherited spinocerebellar ataxias (SCAs) are a large and diverse group of
neurodegenerative diseases. The most prevalent SCAs (SCA1, SCA2, SCA3, SCA6 and …

Autistic-like behaviour and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice

PT Tsai, C Hull, YX Chu, E Greene-Colozzi… - Nature, 2012 - nature.com
Autism spectrum disorders (ASDs) are highly prevalent neurodevelopmental disorders, but
the underlying pathogenesis remains poorly understood. Recent studies have implicated the …

Bidirectional learning in upbound and downbound microzones of the cerebellum

CI De Zeeuw - Nature Reviews Neuroscience, 2021 - nature.com
Over the past several decades, theories about cerebellar learning have evolved. A relatively
simple view that highlighted the contribution of one major form of heterosynaptic plasticity to …

Encoding of action by the Purkinje cells of the cerebellum

DJ Herzfeld, Y Kojima, R Soetedjo, R Shadmehr - Nature, 2015 - nature.com
Execution of accurate eye movements depends critically on the cerebellum,,, suggesting that
the major output neurons of the cerebellum, Purkinje cells, may predict motion of the eye …

Distributed synergistic plasticity and cerebellar learning

Z Gao, BJ Van Beugen, CI De Zeeuw - Nature Reviews Neuroscience, 2012 - nature.com
Studies on synaptic plasticity in the context of learning have been dominated by the view
that a single, particular type of plasticity forms the underlying mechanism for a particular type …

Seeking a unified framework for cerebellar function and dysfunction: from circuit operations to cognition

E D'Angelo, S Casali - Frontiers in neural circuits, 2013 - frontiersin.org
Following the fundamental recognition of its involvement in sensory-motor coordination and
learning, the cerebellum is now also believed to take part in the processing of cognition and …

The cerebellar cortex

C Hull, WG Regehr - Annual review of neuroscience, 2022 - annualreviews.org
The cerebellar cortex is an important system for relating neural circuits and learning. Its
promise reflects the longstanding idea that it contains simple, repeated circuit modules with …

Cerebellar modules operate at different frequencies

H Zhou, Z Lin, K Voges, C Ju, Z Gao, LWJ Bosman… - elife, 2014 - elifesciences.org
Due to the uniform cyto-architecture of the cerebellar cortex, its overall physiological
characteristics have traditionally been considered to be homogeneous. In this study, we …