Osteoarthritis (OA) is one of the most common chronic conditions in the world today. It results
in breakdown of cartilage in joints and causes the patient to experience intense pain and …

Osteoarthritis (OA) is the most prevalent degenerative joint disease. Besides loss of articular
cartilage and synovial inflammation, OA progression is characterized by pathological …

Osteoarthritis (OA) is a widespread joint disease for which there are no disease-modifying
treatments. Previously, we found that mice with cartilage-specific epidermal growth factor …

Oxidative stress and the reactive oxygen species (ROS) have important roles in
osteoarthritis (OA) development and progression. Scavenging ROS by exogenous …

Introductions Excessive mechanical stress is closely associated with cell death in various
conditions. Exposure of chondrocytes to excessive mechanical loading leads to a catabolic …

Osteoarthritis (OA) is a common articular degenerative disease characterized by loss of
cartilage matrix and subchondral bone sclerosis. Kartogenin (KGN) has been reported to …

Osteoarthritis (OA) is a degenerative disease with a series of metabolic changes
accompanied by many altered enzymes. Here, we report that the down-regulated …

Treating osteoarthritis (OA) remains a major clinical challenge. Despite recent advances in
drug discovery and development, no disease-modifying drug for knee OA has emerged with …

Objective To elucidate the role of decorin, a small leucine‐rich proteoglycan, in the
degradation of cartilage matrix during the progression of post‐traumatic osteoarthritis (OA) …

Intervertebral disc degeneration (IVDD) is one of the most prevalent spinal degenerative
disorders and imposes places heavy medical and economic burdens on individuals and …