Social isolation: An underappreciated determinant of physical health

J Holt-Lunstad, A Steptoe - Current opinion in psychology, 2022 - Elsevier
While a sizable body of research demonstrates the associations between social connection
and health, much of the recent focus in the broader public and to some extent among …

The relationship between social isolation, social support, and loneliness with cardiovascular disease and shared risk factors: A narrative review

AB Teshale, HL Htun, J Hu, LL Dalli, MH Lim… - Archives of gerontology …, 2023 - Elsevier
Background Cardiovascular disease (CVD) is the greatest contributor to global morbidity
and mortality. Poor social health plays a critical role in CVD incidence. Additionally, the …

Loneliness and risk for cardiovascular disease: mechanisms and future directions

E Paul, F Bu, D Fancourt - Current cardiology reports, 2021 - Springer
Purpose of review In this review, we synthesise recent research on the association between
loneliness and cardiovascular disease (CVD). We present evidence for mechanisms …

Social isolation shortens lifespan through oxidative stress in ants

A Koto, M Tamura, PS Wong, S Aburatani… - Nature …, 2023 - nature.com
Social isolation negatively affects health, induces detrimental behaviors, and shortens
lifespan in social species. Little is known about the mechanisms underpinning these effects …

Mental health outcomes in health care providers during the COVID-19 pandemic: an umbrella review

U Majid, SAS Hussain, A Zahid… - Health Promotion …, 2023 - academic.oup.com
As we head into the third year of the COVID-19 pandemic, there is an increasing need to
consider the long-term mental health outcomes of health care workers (HCWs) who have …

Effects of long-term social isolation on central, behavioural and metabolic parameters in middle-aged mice

ID Benfato, ACS Quintanilha, JS Henrique… - Behavioural brain …, 2022 - Elsevier
Social isolation gained discussion momentum due to the COVID-19 pandemic. Whereas
many studies address the effects of long-term social isolation in post-weaning and …

Social deprivation induces astrocytic TRPA1-GABA suppression of hippocampal circuits

YT Cheng, J Woo, E Luna-Figueroa, E Maleki… - Neuron, 2023 - cell.com
Social experience is essential for the development and maintenance of higher-order brain
function. Social deprivation results in a host of cognitive deficits, and cellular studies have …

Effects of social isolation on the development of anxiety and depression-like behavior in model experiments in animals

GA Grigoryan, IV Pavlova, MI Zaichenko - Neuroscience and behavioral …, 2022 - Springer
This review describes the role of social isolation in the development of anxiety and
depression-like behavior in rodents. The duration of social isolation, age from onset of social …

The keystone gut species Christensenella minuta boosts gut microbial biomass and voluntary physical activity in mice

T Akbuğa-Schön, TA Suzuki, D Jakob, DL Vu… - Mbio, 2024 - Am Soc Microbiol
The gut bacteria of the family Christensenellaceae are consistently associated with
metabolic health, but their role in promoting host health is not fully understood. Here, we …

The impact of stress on the hippocampal spatial code

A Tomar, TJ McHugh - Trends in Neurosciences, 2022 - cell.com
Hippocampal function is severely compromised by prolonged, uncontrollable stress.
However, how stress alters neural representations of our surroundings and events that occur …