The number and subunit composition of synaptic N-methyl-d-aspartate receptors (NMDARs)
are not static, but change in a cell-and synapse-specific manner during development and in …

Long-term potentiation and long-term depression are processes that have been widely
studied to understand the molecular basis of information storage in the brain. Glutamate …

Excitotoxicity induced by NMDA receptor (NMDAR) activation is a major cause of neuronal
death in ischemic stroke. However, past efforts of directly targeting NMDARs have …

Excitotoxicity contributes to neuronal degeneration in many acute CNS diseases, including
ischemia, trauma, and epilepsy, and may also play a role in chronic diseases, such as …

NMDA-type glutamate receptors (NMDARs) mediate many forms of synaptic plasticity. These
tetrameric receptors consist of two obligatory NR1 subunits and two regulatory subunits …

Stroke and neurotrauma mediate neuronal death through a series of events that involve
multiple interdependent molecular pathways. It has been suggested that these pathways are …

The N‐methyl‐D‐aspartate receptors (NMDARs) are ionotropic glutamate receptors that
mediate the flux of calcium (Ca2+) into the post‐synaptic compartment. Ca2+ influx …

Excitotoxicity is one of the most extensively studied processes of neuronal cell death, and
plays an important role in many central nervous system (CNS) diseases, including CNS …

To elucidate mechanisms controlling the number and subunit composition of synaptic NMDA-
Rs in hippocampal slice neurons, the NR1, NR2A, and NR2B subunits were optically and …

N-Methyl-d-aspartate (NMDA) receptors are critical for neuronal development and synaptic
plasticity. The molecular mechanisms underlying the synaptic localization and functional …