Treatment of Cryptococcal meningitis: how have we got here and where are we going?

NTT Ngan, B Flower, JN Day - Drugs, 2022 - Springer
Cryptococcal meningitis is a devastating brain infection cause by encapsulated yeasts of the
Cryptococcus genus. Exposure, through inhalation, is likely universal by adulthood, but …

[HTML][HTML] Reimagining the future of African brain health: perspectives for basic research on the pathogenesis of cryptococcal meningitis

R Dangarembizi - Brain, Behavior, & Immunity-Health, 2021 - Elsevier
Cryptococcal meningitis is a fatal opportunistic infection of the brain and a leading cause of
neurological damage and death in immunocompromised individuals. This neglected fungal …

Arginase 1 expression by macrophages promotes Cryptococcus neoformans proliferation and invasion into brain microvascular endothelial cells

A Hansakon, C Ngamphiw, S Tongsima… - The Journal of …, 2023 - journals.aai.org
Cryptococcal meningoencephalitis caused by Cryptococcus neoformans infection is the
most common cause of death in HIV/AIDS patients. Macrophages are pivotal for the …

Functional aspects, phenotypic heterogeneity, and tissue immune response of macrophages in infectious diseases

JR de Sousa, PF Da Costa Vasconcelos… - Infection and Drug …, 2019 - Taylor & Francis
Macrophages are a functionally heterogeneous group of cells with specialized functions
depending not only on their subgroup but also on the function of the organ or tissue in which …

Persisting Cryptococcus yeast species Vishniacozyma victoriae and Cryptococcus neoformans elicit unique airway inflammation in mice following repeated …

RE Rush, CB Blackwood, AR Lemons… - Frontiers in Cellular …, 2023 - frontiersin.org
Background Allergic airway disease (AAD) is a growing concern in industrialized nations
and can be influenced by fungal exposures. Basidiomycota yeast species such as …

Cryptococcal protease (s) and the activation of SARS-CoV-2 spike (S) protein

N Mjokane, M Maliehe, OS Folorunso, AO Ogundeji… - Cells, 2022 - mdpi.com
In this contribution, we report on the possibility that cryptococcal protease (s) could activate
the SARS-CoV-2 spike (S) protein. The S protein is documented to have a unique four …

Liposomal Ellagic Acid Alleviates Cyclophosphamide-Induced Toxicity and Eliminates the Systemic Cryptococcus neoformans Infection in Leukopenic Mice

MA Khan, A Khan, M Azam, KS Allemailem, F Alrumaihi… - Pharmaceutics, 2021 - mdpi.com
Cryptococcus neoformans infections rose sharply due to rapid increase in the numbers of
immunocompromised individuals in recent years. Treatment of Cryptococcosis in …

The pathways and the mechanisms by which Cryptococcus enters the brain

Y Zhou, Y Huang, C Yang, X Zang, H Deng, J Liu… - Mycology, 2024 - Taylor & Francis
Generally, Cryptococcus initially infects the respiratory tract, but can spread, eventually
crossing the blood-brain barrier (BBB) and causing meningitis or meningoencephalitis …

Glucuronoxylomannan in the Cryptococcus species capsule as a target for Chimeric Antigen Receptor T-cell therapy

TA da Silva, PJ Hauser, I Bandey, T Laskowski… - Cytotherapy, 2021 - Elsevier
Abstract Background aims The genus Cryptococcus comprises two major fungal species that
cause clinical infections in humans: Cryptococcus gattii and Cryptococcus neoformans. To …

Biomolecular activity of cryptococcus during cryptococcosis: A review of molecular interactions of cryptococcus with human immune system and blood-brain-barrier

J Julian, R Adawiyah, S Wahdini - African Journal of Infectious Diseases, 2024 - ajol.info
Global mycosis is still a problem. One of these is the cryptococcal disease. A systemic
mycosis brought on by Cryptococcus is called cryptococcosis. Host immunological …